Pre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials

British Journal of Cancer. 2020;123(10):1496-1501. doi: 10.1038/s41416-020-01033-x

Our objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical toxicity reported in patients participating in Phase 1 oncology clinical trials.

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