00968nas a2200277   4500000000100000000000100001008004100002260001200043653001800055653001300073100002300086700002000109700001700129700003000146700001400176700002100190700001600211700002100227700001800248245010700266856005500373300001400428490000800442520022600450022001400676       2020                            d  c2020-1110aComorbidities10aOncology1 aJohnique T. Atkins1 aGoldy C. George1 aKenneth Hess1 aKathrina L. Marcelo-Lewis1 aYing Yuan1 aGautam Borthakur1 aSean Khozin1 aPatricia LoRusso1 aDavid S. Hong00aPre-clinical animal models are poor predictors of human toxicities in phase 1 oncology clinical trials  uhttps://www.nature.com/articles/s41416-020-01033-x  a1496-15010 v1233 aOur objective was to determine the correlation between preclinical toxicity found in animal models (mouse, rat, dog and monkey) and clinical toxicity reported in patients participating in Phase 1 oncology clinical trials.  a1532-1827