Translation and validation

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Dilyana Filipova, Wolfgang Boomgaarden, Leyla Fox, et al. Need for NAMs: A systematic evidence synthesis revealing over half a century of drug development failure. NAM Journal. 2026:100119. doi:10.1016/j.namjnl.2026.100119
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Xu Han, Kehan Ren, Pan Wang, et al. Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans. Nature Genetics. 2026:1-12. doi:10.1038/s41588-026-02671-2
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Judith C. Madden, Steven J. Enoch, Alicia Paini, Mark T.D. Cronin. Redefining the gold standard and recommendations to accelerate the adoption of New Approach Methodologies (NAMs) in support of the Three Rs. Alternatives to Laboratory Animals. 2026;54(2):85-100. doi:10.1177/02611929261423850
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Fernando Pardo-Manuel de Villena, James M. Amos-Landgraf, Timothy A. Bell, et al. Improve genetic quality control to increase rigor and reproducibility of mouse research. Science. 2026;392(6799):698-700. doi:10.1126/science.aec3177
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Alexis R. Katz, Margaret P. Huntwork, Jay K. Kolls, et al. Impact of psychological stressors on natural killer cell function: A comprehensive analysis based on stressor type, duration, intensity, and species. Physiology & Behavior. 2025;288:114734. doi:10.1016/j.physbeh.2024.114734
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Hamideh Frühwein, Norbert W. Paul. “Lost in translation?” Animal research in the era of precision medicine. Journal of Translational Medicine. 2025;23(1):152. doi:10.1186/s12967-025-06084-3
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Sarah E. Wolfensohn, Vera Baumans, F. Josef van der Staay, Saskia S. Arndt. Implications of stress for animal welfare and animal-based research†. Laboratory Animals. 2025:00236772251396310. doi:10.1177/00236772251396310
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Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan. Impact of Model-Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost. Clinical Pharmacology & Therapeutics. 2025;118(2):378-385. doi:10.1002/cpt.3636
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Guiyoung Park, Yeri Alice Rim, Yeowon Sohn, Yoojun Nam, Ji Hyeon Ju. Replacing Animal Testing with Stem Cell-Organoids: Advantages and Limitations. Stem Cell Reviews and Reports. 2024. doi:10.1007/s12015-024-10723-5
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Ingrid Berg, Pia Härvelid, Wolfgang Emanuel Zürrer, Marianna Rosso, Daniel S. Reich, Benjamin Victor Ineichen. Which experimental factors govern successful animal-to-human translation in multiple sclerosis drug development? A systematic review and meta-analysis. eBioMedicine. 2024;110. doi:10.1016/j.ebiom.2024.105434
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