Translation and validation

Jarrod Bailey, Michael Balls. Chapter 5 - Case studies on the failures of animal research. In: Catharine E. Krebs, Gail A. Van Norman, eds. Moving Toward Nonanimal Approaches in Medical Research and Testing. Academic Press; 2027:73-85. https://www.sciencedirect.com/science/article/pii/B9780443265143000114.

Pound Pandora. Chapter 3 - The validity and translatability of preclinical animal research. In: Catharine E. Krebs, Gail A. Van Norman, eds. Moving Toward Nonanimal Approaches in Medical Research and Testing. Academic Press; 2027:39-51. https://www.sciencedirect.com/science/article/pii/B9780443265143000163.

Xu Han, Kehan Ren, Pan Wang, et al. Spatial transcriptomic analyses highlight distinct erythroid niches in mice and humans. Nature Genetics. 2026:1-12. doi:10.1038/s41588-026-02671-2

Fernando Pardo-Manuel de Villena, James M. Amos-Landgraf, Timothy A. Bell, et al. Improve genetic quality control to increase rigor and reproducibility of mouse research. Science. 2026;392(6799):698-700. doi:10.1126/science.aec3177

Judith C. Madden, Steven J. Enoch, Alicia Paini, Mark T.D. Cronin. Redefining the gold standard and recommendations to accelerate the adoption of New Approach Methodologies (NAMs) in support of the Three Rs. Alternatives to Laboratory Animals. 2026;54(2):85-100. doi:10.1177/02611929261423850

Dilyana Filipova, Wolfgang Boomgaarden, Leyla Fox, et al. Need for NAMs: A systematic evidence synthesis revealing over half a century of drug development failure. NAM Journal. 2026:100119. doi:10.1016/j.namjnl.2026.100119

Carolyne Jie Huang, Samuel Pawel, Kimberley Elaine Wever, Benjamin Victor Ineichen, Rachel Heyard. Evaluating the applicability of replication success metrics in animal-to-human translation: A simulation study. George N Okoli, Eduardo L Franco, eds. eLife. 2026;15:RP109853. doi:10.7554/eLife.109853

Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan. Impact of Model-Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost. Clinical Pharmacology & Therapeutics. 2025;118(2):378-385. doi:10.1002/cpt.3636

Hamideh Frühwein, Norbert W. Paul. “Lost in translation?” Animal research in the era of precision medicine. Journal of Translational Medicine. 2025;23(1):152. doi:10.1186/s12967-025-06084-3

Alexis R. Katz, Margaret P. Huntwork, Jay K. Kolls, et al. Impact of psychological stressors on natural killer cell function: A comprehensive analysis based on stressor type, duration, intensity, and species. Physiology & Behavior. 2025;288:114734. doi:10.1016/j.physbeh.2024.114734