Vanda Pharmaceuticals Inc. is a leading global biopharmaceutical company focused on the development and commercialization of innovative therapies to address high unmet medical needs and improve the lives of patients. Vanda’s vision is to avoid in vivo animal studies and replace them with the use of alternatives to support scientific discovery, protecting and enhancing the welfare of animals used in scientific research while advancing research and development through the use of optimal human-specific models. The commercial perspective has shifted toward nonanimal methods, driven by scientific rigor, efficiency, ethical implications, and cost-effectiveness. Similarly, the academic perspective has focused on the scientific innovation and mechanistic understanding of the use of alternative methods. We are also witnessing a societal shift toward more humane research practices that minimize animal suffering. However, broader industry adoption relies on these methods meeting regulatory approval. One potential route would be to reject the approach of global harmonization of animal methods, which relies on unsupported concepts often elevated to impose false gold standards.
Moving Toward Nonanimal Approaches in Medical Research and Testing.
Academic Press;
2027:233-241.
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