microphysiological systems

Konrad Schmidt, Alessandro Bentivogli, Sarah Hedtrich. Chapter 6 - Microphysiological systems. In: Catharine E. Krebs, Gail A. Van Norman, eds. Moving Toward Nonanimal Approaches in Medical Research and Testing. Academic Press; 2027:89-103. https://www.sciencedirect.com/science/article/pii/B9780443265143000023.

Sandra P. Smieszek, Christina Tyner, Mihael H. Polymeropoulos. Chapter 14 - Perspectives from pharmaceutical industry regarding nonanimal-based research and testing. In: Catharine E. Krebs, Gail A. Van Norman, eds. Moving Toward Nonanimal Approaches in Medical Research and Testing. Academic Press; 2027:233-241. https://www.sciencedirect.com/science/article/pii/B9780443265143000096.

Patrizia Tornabene, Estelle Berreur, Adrian Roth, Magdalena Kasendra. Microphysiological systems to accelerate and de-risk AAV gene therapy development. Advanced Drug Delivery Reviews. 2026;233:115841. doi:10.1016/j.addr.2026.115841

Nilanjan Roy, Luca Cucullo. Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation. Biosensors. 2026;16(3). doi:10.3390/bios16030155

Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler. Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips. Advanced Biology. 2026;10(2):e00536. doi:10.1002/adbi.202500536

K. Taylor, R. Ram, L. Ewart, et al. Perspective: How complex in vitro models are addressing the challenges of predicting drug-induced liver injury. Frontiers in Drug Discovery. 2025;5. doi:10.3389/fddsv.2025.1536756

Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046

Aakash Patel, Suruchi Poddar, Daniel Nierenberg, et al. Microphysiological system to address the opioid crisis: A novel multi-organ model of acute opioid overdose and recovery. Current Research in Toxicology. 2025;8:100209. doi:10.1016/j.crtox.2024.100209

Kristifor Sunderic, Andrew M. Wright, Nicole Kleinstreuer, et al. Complement-ARIE: Catalyzing the development and adoption of new approach methodologies. NAM Journal. 2025;1:100026. doi:10.1016/j.namjnl.2025.100026

Katharina Stefanie Nitsche, Iris Müller, Sophie Malcomber, Paul Lawford Carmichael, Hans Bouwmeester. Alternatives to animal-derived extracellular matrix hydrogels? An explorative study with HepaRG cells in animal-free hydrogels under static and dynamic culture conditions. Frontiers in Toxicology. 2025;7. doi:10.3389/ftox.2025.1649393