Reviews and perspectives

Zehra Yildirim, Kyle Swanson, Xuekun Wu, James Zou, Joseph Wu. Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish. Annual Review of Pharmacology and Toxicology. 2025;65(Volume 65, 2025):71-90. doi:10.1146/annurev-pharmtox-022724-095035

Tina Woods, Nic Palmarini, Lynne Corner, et al. Cities, communities and clinics can be testbeds for human exposome and aging research. Nature Medicine. 2025:1-3. doi:10.1038/s41591-025-03519-8

AM Anu Varshini, Usha Nandini S, V Ramesh Kumar, Thangam T, Krupakar Parthasarathy. New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model. NAM Journal. 2025;1:100003. doi:10.1016/j.namjnl.2024.100003

Saif F. Dababneh, Hosna Babini, Verónica Jiménez-Sábado, Sheila S. Teves, Kyoung-Han Kim, Glen F. Tibbits. Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models. Stem Cell Reports. 2025;20(4). doi:10.1016/j.stemcr.2025.102467

Uwe Marx, Sonja Beken, Zaozao Chen, et al. Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare. ALTEX - Alternatives to animal experimentation. 2025;42(2):204-223. doi:10.14573/altex.2410112

Thomas Hartung, Lena Smirnova. A path forward advancing microphysiological systems. ALTEX - Alternatives to animal experimentation. 2025;42(2):183-203. doi:10.14573/altex.2504091

Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046

Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, et al. Human-based complex in vitro models: their promise and potential for rare disease therapeutics. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1526306

Monique M. A. Verstegen, Rob P. Coppes, Anne Beghin, et al. Clinical applications of human organoids. Nature Medicine. 2025:1-13. doi:10.1038/s41591-024-03489-3

Lena Smirnova, Thomas Hartung. The Promise and Potential of Brain Organoids. Advanced Healthcare Materials. 2024:2302745. doi:10.1002/adhm.202302745