Reviews and perspectives

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Nilanjan Roy, Luca Cucullo. Organs-on-Chips in Drug Development: Engineering Foundations, Artificial Intelligence, and Clinical Translation. Biosensors. 2026;16(3). doi:10.3390/bios16030155
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Franziska Buck, Jeroen Bugter, Gizem Yorukoglu, Mina Kazemzadeh Dastjerd, Thomas E. Winkler. Personalized Models of Biological Barriers and Their Diseases: Recent Progress with Organs-On-Chips. Advanced Biology. 2026;10(2):e00536. doi:10.1002/adbi.202500536
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Donna S. Macmillan, Phi Holcomb, Kristie M. Sullivan. Lost in NAMs-lation: A review of animal-free science definitions. ALTEX - Alternatives to Animal Experimentation. 2026. doi:10.14573/altex.2512221
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Thomas Hartung, Lena Smirnova. A path forward advancing microphysiological systems. ALTEX - Alternatives to animal experimentation. 2025;42(2):183-203. doi:10.14573/altex.2504091
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Kang Zhang, Xin Yang, Yifei Wang, et al. Artificial intelligence in drug development. Nature Medicine. 2025;31(1):45-59. doi:10.1038/s41591-024-03434-4
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Uwe Marx, Sonja Beken, Zaozao Chen, et al. Biology-inspired dynamic microphysiological system approaches to revolutionize basic research, healthcare and animal welfare. ALTEX - Alternatives to animal experimentation. 2025;42(2):204-223. doi:10.14573/altex.2410112
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Saif F. Dababneh, Hosna Babini, Verónica Jiménez-Sábado, Sheila S. Teves, Kyoung-Han Kim, Glen F. Tibbits. Dissecting cardiovascular disease-associated noncoding genetic variants using human iPSC models. Stem Cell Reports. 2025;20(4). doi:10.1016/j.stemcr.2025.102467
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AM Anu Varshini, Usha Nandini S, V Ramesh Kumar, Thangam T, Krupakar Parthasarathy. New frontiers in anti-cancer drug testing: The need for a relevant In vitro testing model. NAM Journal. 2025;1:100003. doi:10.1016/j.namjnl.2024.100003
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Monique M. A. Verstegen, Rob P. Coppes, Anne Beghin, et al. Clinical applications of human organoids. Nature Medicine. 2025:1-13. doi:10.1038/s41591-024-03489-3
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Hiroshi Kimura, Masaki Nishikawa, Naokata Kutsuzawa, et al. Advancements in Microphysiological systems: Exploring organoids and organ-on-a-chip technologies in drug development -focus on pharmacokinetics related organs-. Drug Metabolism and Pharmacokinetics. 2025;60:101046. doi:10.1016/j.dmpk.2024.101046
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