Reviews and perspectives

Zehra Yildirim, Kyle Swanson, Xuekun Wu, James Zou, Joseph Wu. Next-Gen Therapeutics: Pioneering Drug Discovery with iPSCs, Genomics, AI, and Clinical Trials in a Dish. Annual Review of Pharmacology and Toxicology. 2025;65(Volume 65, 2025):71-90. doi:10.1146/annurev-pharmtox-022724-095035

Monique M. A. Verstegen, Rob P. Coppes, Anne Beghin, et al. Clinical applications of human organoids. Nature Medicine. 2025:1-13. doi:10.1038/s41591-024-03489-3

Surat Parvatam, Francesca Pistollato, Lindsay J. Marshall, et al. Human-based complex in vitro models: their promise and potential for rare disease therapeutics. Frontiers in Cell and Developmental Biology. 2025;13. doi:10.3389/fcell.2025.1526306

Francesca Pistollato, Fabia Furtmann, Sarah Abitbol, et al. Leveraging innovative research tools to meet public health challenges: a BioMed21 workshop report. NAM Journal. 2025;1:100023. doi:10.1016/j.namjnl.2025.100023

Lilly Tozer. Organoids grown from amniotic fluid could shed light on rare diseases. Nature. 2024. https://www.nature.com/articles/d41586-024-00656-x.

Lena Smirnova, Thomas Hartung. The Promise and Potential of Brain Organoids. Advanced Healthcare Materials. 2024:2302745. doi:10.1002/adhm.202302745

Derrick Butler, Darwin R. Reyes. Heart-on-a-chip systems: disease modeling and drug screening applications. Lab on a Chip. 2024;24(5):1494-1528. doi:10.1039/D3LC00829K

Mauricio Goncalves da Costa Sousa, Sofia M. Vignolo, Cristiane Miranda Franca, et al. Engineering models of head and neck and oral cancers on-a-chip. Biomicrofluidics. 2024;18:021502. doi:10.1063/5.0186722

Caitlin Lynch, Srilatha Sakamuru, Masato Ooka, et al. High-Throughput Screening to Advance In Vitro Toxicology: Accomplishments, Challenges, and Future Directions. Annual Review of Pharmacology and Toxicology. 2024;64(Volume 64, 2024):191-209. doi:10.1146/annurev-pharmtox-112122-104310

Raquel Alonso-Roman, Alexander S. Mosig, Marc Thilo Figge, et al. Organ-on-chip models for infectious disease research. Nature Microbiology. 2024:1-14. doi:10.1038/s41564-024-01645-6