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Experimental liver models: From cell culture techniques to microfluidic organs-on-chip
ReferenceMichela Anna Polidoro , Erika Ferrari , Simona Marzorati , Ana Lleo , Marco Rasponi Liver International: Official Journal of the International Association for the Study of the Liver. 2021;41(8):1744-1761. doi: 10.1111/liv.14942 The liver is one of the …
Is animal research sufficiently evidence based to be a cornerstone of biomedical research?
ReferencePandora Pound , Michael B. Bracken BMJ. 2014;348:g3387. doi: 10.1136/bmj.g3387 https://www.bmj.com/content/348/bmj.g3387 Library Collection(s) Translation and validation Download Citation BibTeX EndNote X3 XML EndNote 7 XML EndNote tagged Marc …
Limitations of Animal Studies for Predicting Toxicity in Clinical Trials: Is it Time to Rethink Our Current Approach?
ReferenceGail A. Van Norman JACC. Basic to translational science. 2019;4(7):845-854. doi: 10.1016/j.jacbts.2019.10.008 Animal testing is used in pharmaceutical and industrial research to predict human toxicity, and yet analysis suggests that animal models are poor …
Machine learning models to accelerate the design of polymeric long-acting injectables
ReferencePauric Bannigan , Zeqing Bao , Riley J. Hickman , Matteo Aldeghi , Florian Häse , Alán Aspuru-Guzik , Christine Allen Nature Communications. 2023;14(1):35. doi: 10.1038/s41467-022-35343-w Long-acting injectables are considered one of the most promising …
Mapping PTSD symptoms to brain networks: a machine learning study
ReferenceZandvakili A , Barredo J , Swearingen Hr , Aiken Em , Berlow Ya , Greenberg Bd , Carpenter Ll , Philip Ns Translational psychiatry. 6;10(1). doi: 10.1038/s41398-020-00879-2 Posttraumatic Stress Disorder (PTSD) is a prevalent and debilitating condition …
Medical progress depends on animal models - doesn't it?
ReferenceRobert A. J. Matthews Journal of the Royal Society of Medicine. 2008;101(2):95-98. doi: 10.1258/jrsm.2007.070164 https://journals.sagepub.com/doi/10.1258/jrsm.2007.070164 Keywords animal experimentation Animals Disease Models, Animal Evidence-Based …
Microfluidic organ-on-chip system for multi-analyte monitoring of metabolites in 3D cell cultures
ReferenceJohannes Dornhof , Jochen Kieninger , Harshini Muralidharan , Jochen Maurer , Gerald A. Urban , Andreas Weltin Lab on a Chip. 2022;22(2):225-239. doi: 10.1039/D1LC00689D Three-dimensional cell cultures using patient-derived stem cells are essential in …
Minilungs from Human Embryonic Stem Cells to Study the Interaction of Streptococcus pneumoniae with the Respiratory Tract
ReferenceJulio Sempere , Suélen Andreia Rossi , Irene Chamorro-Herrero , Fernando González-Camacho , MarÃa Pilar de Lucas , José MarÃa Rojas-Cabañeros , Carlos Pelleschi Taborda , Óscar Zaragoza , José Yuste , Alberto Zambrano Microbiology Spectrum. …
Modeling Neurodegenerative Diseases Using In Vitro Compartmentalized Microfluidic Devices
ReferenceLouise Miny , Benoît G. C. Maisonneuve , Isabelle Quadrio , Thibault Honegger Frontiers in Bioengineering and Biotechnology. 2022;10:919646. doi: 10.3389/fbioe.2022.919646 The human brain is a complex organ composed of many different types of cells …
On the Evaluation of a Novel Hypoxic 3D Pancreatic Cancer Model as a Tool for Radiotherapy Treatment Screening
ReferenceGabrielle Wishart , Priyanka Gupta , Andrew Nisbet , Giuseppe Schettino , Eirini Velliou Cancers. 2021;13(23):6080. doi: 10.3390/cancers13236080 Tissue engineering is evolving to mimic intricate ecosystems of tumour microenvironments (TME) to more readily …