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Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems
ReferenceRiccardo Barrile , Andries D. van der Meer , Hyoungshin Park , Jacob P. Fraser , Damir Simic , Fang Teng , David Conegliano , Justin Nguyen , Abhishek Jain , Mimi Zhou , Katia Karalis , Donald E. Ingber , Geraldine A. Hamilton , Monicah A. Otieno Clinical …
Organoid cultures from normal and cancer-prone human breast tissues preserve complex epithelial lineages
ReferenceJennifer M. Rosenbluth , Ron C. J. Schackmann , G. Kenneth Gray , Laura M. Selfors , Carman Man-Chung Li , Mackenzie Boedicker , Hendrik J. Kuiken , Andrea Richardson , Jane Brock , Judy Garber , Deborah Dillon , Norman Sachs , Hans Clevers , Joan S. …
Organoid modeling of human fetal lung alveolar development reveals mechanisms of cell fate patterning and neonatal respiratory disease
ReferenceKyungtae Lim , Alex P. A. Donovan , Walfred Tang , Dawei Sun , Peng He , J. Patrick Pett , Sarah A. Teichmann , John C. Marioni , Kerstin B. Meyer , Andrea H. Brand , Emma L. Rawlins Cell Stem Cell. 2023;30(1):20-37.e9. doi: 10.1016/j.stem.2022.11.013 …
Organoids from patient biopsy samples can predict the response of BC patients to neoadjuvant chemotherapy
ReferenceDan Shu , Meiying Shen , Kang Li , Xiaojian Han , Han Li , Zhaofu Tan , Yu Wang , Yang Peng , Zhenrong Tang , Chi Qu , Aishun Jin , Shengchun Liu Annals of Medicine. 2022;54(1):2581-2597. doi: 10.1080/07853890.2022.2122550 PROPOSE: Neoadjuvant …
Organoids in cancer research
ReferenceJarno Drost , Hans Clevers Nature Reviews. Cancer. 2018;18(7):407-418. doi: 10.1038/s41568-018-0007-6 The recent advances in in vitro 3D culture technologies, such as organoids, have opened new avenues for the development of novel, more physiological …
Modeling Development and Disease with Organoids
ReferenceHans Clevers Cell. 2016;165(7):1586-1597. doi: 10.1016/j.cell.2016.05.082 Recent advances in 3D culture technology allow embryonic and adult mammalian stem cells to exhibit their remarkable self-organizing properties, and the resulting organoids reflect …
Cancer stem cells revisited
ReferenceEduard Batlle , Hans Clevers Nature Medicine. 2017;23(10):1124-1134. doi: 10.1038/nm.4409 The cancer stem cell (CSC) concept was proposed four decades ago, and states that tumor growth, analogous to the renewal of healthy tissues, is fueled by small …
Patient-derived micro-organospheres enable clinical precision oncology
ReferenceShengli Ding , Carolyn Hsu , Zhaohui Wang , Naveen R. Natesh , Rosemary Millen , Marcos Negrete , Nicholas Giroux , Grecia O. Rivera , Anders Dohlman , Shree Bose , Tomer Rotstein , Kassandra Spiller , Athena Yeung , Zhiguo Sun , Chongming Jiang , Rui Xi …
Long-term expanding human airway organoids for disease modeling
ReferenceNorman Sachs , Angelos Papaspyropoulos , Domenique D. Zomer-van Ommen , Inha Heo , Lena Böttinger , Dymph Klay , Fleur Weeber , Guizela Huelsz-Prince , Nino Iakobachvili , Gimano D. Amatngalim , Joep de Ligt , Arne van Hoeck , Natalie Proost , Marco C. …
Organoids in immunological research
ReferenceYotam E. Bar-Ephraim , Kai Kretzschmar , Hans Clevers Nature Reviews. Immunology. 2020;20(5):279-293. doi: 10.1038/s41577-019-0248-y Much of our knowledge regarding the interactions between epithelial tissues and the immune system has been gathered from …