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Intestinal organoid cocultures with microbes
ReferenceJens Puschhof , Cayetano Pleguezuelos-Manzano , Adriana Martinez-Silgado , Ninouk Akkerman , Aurelia Saftien , Charelle Boot , Amy de Waal , Joep Beumer , Devanjali Dutta , Inha Heo , Hans Clevers Nature Protocols. 2021;16(10):4633-4649. doi: …
Cancer modeling meets human organoid technology
ReferenceDavid Tuveson , Hans Clevers Science (New York, N.Y.). 2019;364(6444):952-955. doi: 10.1126/science.aaw6985 Organoids are microscopic self-organizing, three-dimensional structures that are grown from stem cells in vitro. They recapitulate many structural …
Establishment of patient-derived cancer organoids for drug-screening applications
ReferenceElse Driehuis , Kai Kretzschmar , Hans Clevers Nature Protocols. 2020;15(10):3380-3409. doi: 10.1038/s41596-020-0379-4 Adult stem cell-based organoid technology is a versatile tool for the generation and long-term maintenance of near-native 3D epithelial …
The Organoid Cell Atlas
ReferenceChristoph Bock , Michael Boutros , J. Gray Camp , Laura Clarke , Hans Clevers , Juergen A. Knoblich , Prisca Liberali , Aviv Regev , Anne C. Rios , Oliver Stegle , Hendrik G. Stunnenberg , Sarah A. Teichmann , Barbara Treutlein , Robert G. J. Vries , …
Organoids and organs-on-chips: Insights into human gut-microbe interactions
ReferenceJens Puschhof , Cayetano Pleguezuelos-Manzano , Hans Clevers Cell Host & Microbe. 2021;29(6):867-878. doi: 10.1016/j.chom.2021.04.002 The important and diverse roles of the gut microbiota in human health and disease are increasingly recognized. The …
Human Organoids: Tools for Understanding Biology and Treating Diseases
ReferenceFrans Schutgens , Hans Clevers Annual Review of Pathology. 2020;15:211-234. doi: 10.1146/annurev-pathmechdis-012419-032611 Organoids are in vitro-cultured three-dimensional structures that recapitulate key aspects of in vivo organs. They can be …
Kidney Organoids and Tubuloids
ReferenceFjodor A. Yousef Yengej , Jitske Jansen , Maarten B. Rookmaaker , Marianne C. Verhaar , Hans Clevers Cells. 2020;9(6):1326. doi: 10.3390/cells9061326 In the past five years, pluripotent stem cell (PSC)-derived kidney organoids and adult stem or progenitor …
A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity
ReferenceNorman Sachs , Joep de Ligt , Oded Kopper , Ewa Gogola , Gergana Bounova , Fleur Weeber , Anjali Vanita Balgobind , Karin Wind , Ana Gracanin , Harry Begthel , Jeroen Korving , Ruben van Boxtel , Alexandra Alves Duarte , Daphne Lelieveld , Arne van Hoeck …
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation
ReferenceGui-Wei He , Lin Lin , Jeff DeMartino , Xuan Zheng , Nadzeya Staliarova , Talya Dayton , Harry Begthel , Willine J. van de Wetering , Eduard Bodewes , Jeroen van Zon , Sander Tans , Carmen Lopez-Iglesias , Peter J. Peters , Wei Wu , Daniel Kotlarz , …
Organoids in gastrointestinal diseases: from experimental models to clinical translation
ReferenceClaudia Günther , Beate Winner , Markus F. Neurath , Thaddeus S. Stappenbeck Gut. 2022;71(9):1892-1908. doi: 10.1136/gutjnl-2021-326560 We are entering an era of medicine where increasingly sophisticated data will be obtained from patients to determine …