Search
Organoid Models of Tumor Immunology
ReferenceKanako Yuki , Ning Cheng , Michitaka Nakano , Calvin J. Kuo Trends in Immunology. 2020;41(8):652-664. doi: 10.1016/j.it.2020.06.010 Cellular interactions in the tumor microenvironment (TME) significantly govern cancer progression and drug response. The …
Intestinal enteroids/organoids: A novel platform for drug discovery in inflammatory bowel diseases
ReferenceJun-Hwan Yoo , Mark Donowitz World Journal of Gastroenterology. 2019;25(30):4125-4147. doi: 10.3748/wjg.v25.i30.4125 The introduction of biologics such as anti-tumor necrosis factor (TNF) monoclonal antibodies followed by anti-integrins has dramatically …
Organoids open fresh paths to biomedical advances
ReferenceMichael Eisenstein Nature. 2022;612(7940):S34-S35. doi: 10.1038/d41586-022-04214-1 Keywords Biological techniques Biomedical Research Drug Discovery Humans medical research organoids Tissue Culture Techniques Library Collection(s) Reviews and perspectives …
Patient-derived pancreatic cancer-on-a-chip recapitulates the tumor microenvironment
ReferenceMuhammad R. Haque , Caitlin R. Wessel , Daniel D. Leary , Chengyao Wang , Abhinav Bhushan , Faraz Bishehsari Microsystems & Nanoengineering. 2022;8:36. doi: 10.1038/s41378-022-00370-6 The patient population suffering from pancreatic ductal adenocarcinoma …
Streptococcus pneumoniae Affects Endothelial Cell Migration in Microfluidic Circulation
ReferenceAnna Kopenhagen , Isabell Ramming , Belinda Camp , Sven Hammerschmidt , Marcus Fulde , Mathias Müsken , Michael Steinert , Simone Bergmann Frontiers in Microbiology. 2022;13:852036. doi: 10.3389/fmicb.2022.852036 Bloodstream infections caused by …
The future of Parkinson's disease research: A new paradigm of human-specific investigation is necessary… and possible
ReferenceManuela Cassotta , Hugo Geerts , Lise Harbom , Tiago F. Outeiro , Iosif Pediaditakis , Orly Reiner , Stefan Schildknecht , Jens C. Schwamborn , Jarrod Bailey , Kathrin Herrmann , Helena T. Hogberg ALTEX. 2022;39(4):694-709. doi: 10.14573/altex.2203161 …
The human element: moving beyond animal models to study the neuronal regulation of intestinal electrolyte transport
ReferenceWallace MacNaughton The Journal of Physiology. 2016;594(2):259-260. doi: 10.1113/JP271771 Keywords Animals Biological Transport Electrolytes Humans Intestinal Absorption Intestinal Mucosa Models, Animal Sodium Library Collection(s) Gastrointestinal system …
Threats to Benefits: Assessing Knowledge Production in Nonhuman Models of Human Neuropsychiatric Disorders
ReferenceCarolyn P. Neuhaus The Hastings Center Report. 2022;52 Suppl 2(Suppl 2):S34-S40. doi: 10.1002/hast.1430 Recent reports and papers on chimeric research highlight the promise of chimeric models of human neuropsychiatric disorders to ameliorate human …
A survey to assess animal methods bias in scientific publishing
ReferenceCatharine E. Krebs , Ann Lam , Janine McCarthy , Helder Constantino , Kristie Sullivan Alternatives to Animal Experimentation. 2023;40(4):665-676. doi: 10.14573/altex.2210212 Publication of scientific findings is fundamental for research, pushing …
The future of academic publishing
ReferenceAbubakari Ahmed , Aceil Al-Khatib , Yap Boum , Humberto Debat , Alonso Gurmendi Dunkelberg , Lisa Janicke Hinchliffe , Frith Jarrad , Adam Mastroianni , Patrick Mineault , Charlotte R. Pennington , J. Andrew Pruszynski Nature Human Behaviour. …