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In vitro Models of Bone Remodelling and Associated Disorders
ReferenceRobert Owen , Gwendolen C. Reilly Frontiers in Bioengineering and Biotechnology. 2018;6:134. doi: 10.3389/fbioe.2018.00134 Disruption of bone remodelling by diseases such as osteoporosis results in an imbalance between bone formation by osteoblasts and …
A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis
ReferenceFrancisco Conceição , Daniela M. Sousa , Joshua Loessberg-Zahl , Anke R. Vollertsen , Estrela Neto , Kent Søe , Joana Paredes , Anne Leferink , Meriem Lamghari Materials Today. Bio. 2022;13:100219. doi: 10.1016/j.mtbio.2022.100219 Organ-on-a-chip models …
Embracing Mechanobiology in Next Generation Organ-On-A-Chip Models of Bone Metastasis
ReferenceEllen E. Slay , Fiona C. Meldrum , Virginia Pensabene , Mahetab H. Amer Frontiers in Medical Technology. 2021;3:722501. doi: 10.3389/fmedt.2021.722501 Bone metastasis in breast cancer is associated with high mortality. Biomechanical cues presented by the …
Bone-on-a-Chip: Biomimetic Models Based on Microfluidic Technologies for Biomedical Applications
ReferenceMin Kyeong Kim , Kyurim Paek , Sang-Mi Woo , Jeong Ah Kim ACS biomaterials science & engineering. 2023;9(6):3058-3073. doi: 10.1021/acsbiomaterials.3c00066 With the increasing importance of preclinical evaluation of newly developed drugs or treatments, in …
Manufacturing a Bone Marrow-On-A-Chip Using Maskless Photolithography
ReferenceBenoit Souquet , Matthieu Opitz , Benoit Vianay , Stéphane Brunet , Manuel Théry Methods in Molecular Biology (Clifton, N.J.). 2021;2308:263-278. doi: 10.1007/978-1-0716-1425-9_20 The bone marrow (BM) is a complex microenvironment in which hematopoietic …
Construction of Bone Hypoxic Microenvironment Based on Bone-on-a-Chip Platforms
ReferenceChen Li , Rong Zhao , Hui Yang , Li Ren International Journal of Molecular Sciences. 2023;24(8):6999. doi: 10.3390/ijms24086999 The normal physiological activities and functions of bone cells cannot be separated from the balance of the oxygenation level, …
Organ-on-a-chip model of vascularized human bone marrow niches
ReferenceDrew E. Glaser , Matthew B. Curtis , Peter A. Sariano , Zachary A. Rollins , Bhupinder S. Shergill , Aravind Anand , Alyssa M. Deely , Venktesh S. Shirure , Leif Anderson , Jeremy M. Lowen , Natalie R. Ng , Katherine Weilbaecher , Daniel C. Link , Steven …
Bone-on-a-chip: microfluidic technologies and microphysiologic models of bone tissue
ReferenceAmin Mansoorifar , Ryan Gordon , Raymond Bergan , Luiz E. Bertassoni Advanced Functional Materials. 2021;31(6):2006796. doi: 10.1002/adfm.202006796 Bone is an active organ that continuously undergoes an orchestrated process of remodeling throughout life. …
Microfluidic organ-on-a-chip models of human liver tissue
ReferenceEhsanollah Moradi , Sasan Jalili-Firoozinezhad , Mehran Solati-Hashjin Acta Biomaterialia. 2020;116:67-83. doi: 10.1016/j.actbio.2020.08.041 The liver is the largest internal organ of the body with complex microarchitecture and function that plays …
Liver organ-on-chip models for toxicity studies and risk assessment
ReferenceTaha Messelmani , Lisa Morisseau , Yasuyuki Sakai , Cécile Legallais , Anne Le Goff , Eric Leclerc , Rachid Jellali Lab on a Chip. 2022;22(13):2423-2450. doi: 10.1039/d2lc00307d The liver is a key organ that plays a pivotal role in metabolism and ensures …