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Modeling multi-organ systems on a chip
ReferenceNina Vogt Nature Methods. 2022;19(6):641-641. doi: 10.1038/s41592-022-01533-z To recapitulate some of the complexities of the human physiology, engineered tissues can be linked by vascular flow in a multi-organ chip. …
Towards establishing human body-on-a-chip systems
ReferenceZhong Alan Li , Rocky S. Tuan Stem Cell Research & Therapy. 2022;13(1):431. doi: 10.1186/s13287-022-03130-5 Body-on-a-chip (BoC) platforms are established from multiple organs-on-chips (OoCs) to recapitulate the interactions between different tissues. …
Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases
ReferenceValentina Paloschi , Maria Sabater-Lleal , Heleen Middelkamp , Aisen Vivas , Sofia Johansson , Andries van der Meer , Maria Tenje , Lars Maegdefessel Cardiovascular Research. 2021;117(14):2742-2754. doi: 10.1093/cvr/cvab088 The development of …
Towards the development of human immune-system-on-a-chip platforms
ReferenceAlessandro Polini , Loretta L. Del Mercato , Adriano Barra , Yu Shrike Zhang , Franco Calabi , Giuseppe Gigli Drug Discovery Today. 2019;24(2):517-525. doi: 10.1016/j.drudis.2018.10.003 Organ-on-a-chip (OoCs) platforms could revolutionize drug discovery …
Integrated technologies for continuous monitoring of organs-on-chips: Current challenges and potential solutions
ReferenceJonathan Sabaté del RÃo , Jooyoung Ro , Heejeong Yoon , Tae-Eun Park , Yoon-Kyoung Cho Biosensors and Bioelectronics. 2023;224:115057. doi: 10.1016/j.bios.2022.115057 Organs-on-chips (OoCs) are biomimetic in vitro systems based on microfluidic cell …
Recent advances in lab-on-a-chip systems for breast cancer metastasis research
ReferenceBurcu Firatligil-Yildirir , Ozden Yalcin-Ozuysal , null Nonappa Nanoscale Advances. 2023;5(9):2375-2393. doi: 10.1039/d2na00823h Breast cancer is the leading cause of cancer-related deaths in women. Multiple molecular subtypes, heterogeneity, and their …
Drug compound screening in single and integrated multi-organoid body-on-a-chip systems
ReferenceAleksander Skardal , Julio Aleman , Steven Forsythe , Shiny Rajan , Sean Murphy , Mahesh Devarasetty , Nima Pourhabibi Zarandi , Goodwell Nzou , Robert Wicks , Hooman Sadri-Ardekani , Colin Bishop , Shay Soker , Adam Hall , Thomas Shupe , Anthony Atala …
Gut-on-a-chip for disease models
ReferenceChangxiu Xian , Jiaxin Zhang , Suqing Zhao , Xiang-Guang Li Journal of Tissue Engineering. 2023;14:20417314221149882. doi: 10.1177/20417314221149882 The intestinal tract is a vital organ responsible for digestion and absorption in the human body and plays …
Design and Evaluation of an Osteogenesis-on-a-Chip Microfluidic Device Incorporating 3D Cell Culture
ReferenceHossein Bahmaee , Robert Owen , Liam Boyle , Cecile M. Perrault , Andres A. Garcia-Granada , Gwendolen C. Reilly , Frederik Claeyssens Frontiers in Bioengineering and Biotechnology. 2020;8:557111. doi: 10.3389/fbioe.2020.557111 Microfluidic-based …
Use of in vitro bone models to screen for altered bone metabolism, osteopathies, and fracture healing: challenges of complex models
ReferenceSabrina Ehnert , Helen Rinderknecht , Romina H. Aspera-Werz , Victor Häussling , Andreas K. Nussler Archives of Toxicology. 2020;94(12):3937-3958. doi: 10.1007/s00204-020-02906-z Approx. every third hospitalized patient in Europe suffers from …