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Geometric engineering of organoid culture for enhanced organogenesis in a dish
ReferenceSunghee Estelle Park , Shawn Kang , Jungwook Paek , Andrei Georgescu , Jeehan Chang , Alex Yoon Yi , Benjamin J. Wilkins , Tatiana A. Karakasheva , Kathryn E. Hamilton , Dan Dongeun Huh Nature Methods. 2022;19(11):1449-1460. doi: …
How Well Do Rodent Models of Parkinson's Disease Recapitulate Early Non-Motor Phenotypes? A Systematic Review
ReferenceTracy D. Zhang , Scott C. Kolbe , Leah C. Beauchamp , Ella K. Woodbridge , David I. Finkelstein , Emma L. Burrows Biomedicines. 2022;10(12):3026. doi: 10.3390/biomedicines10123026 The prodromal phase of Parkinson's disease (PD) is characterised by many …
Human brain organogenesis: Toward a cellular understanding of development and disease
ReferenceKevin W. Kelley , Sergiu P. Pașca Cell. 2022;185(1):42-61. doi: 10.1016/j.cell.2021.10.003 https://www.cell.com/cell/abstract/S0092-8674(21)01177-6 Library Collection(s) Nervous system Download Citation BibTeX EndNote X3 XML EndNote 7 XML EndNote tagged …
Human cerebral organoids - a new tool for clinical neurology research
ReferenceOliver L. Eichmüller , Juergen A. Knoblich Nature Reviews. Neurology. 2022;18(11):661-680. doi: 10.1038/s41582-022-00723-9 The current understanding of neurological diseases is derived mostly from direct analysis of patients and from animal models of …
Human organoids: New strategies and methods for analyzing human development and disease
ReferenceNina S. Corsini , Juergen A. Knoblich Cell. 2022;185(15):2756-2769. doi: 10.1016/j.cell.2022.06.051 https://www.cell.com/cell/abstract/S0092-8674(22)00844-3 Keywords disease In vitro model organoid Stem cells Library Collection(s) Reviews and perspectives …
Impact of the Human Cell Atlas on medicine
ReferenceJennifer E. Rood , Aidan Maartens , Anna Hupalowska , Sarah A. Teichmann , Aviv Regev Nature Medicine. 2022;28(12):2486-2496. doi: 10.1038/s41591-022-02104-7 Single-cell atlases promise to provide a ‘missing link’ between genes, diseases and therapies. By …
Improving Translation by Identifying Evidence for More Human-Relevant Preclinical Strategies
ReferenceMerel Ritskes-Hoitinga , Cathalijn Leenaars , Wouter Beumer , Tineke Coenen-de Roo , Frans Stafleu , Franck L. B. Meijboom Animals: an open access journal from MDPI. 2020;10(7):1170. doi: 10.3390/ani10071170 Preclinical animal studies are performed to …
In preprints: humans, the new model organism
ReferenceJames M. Wells , Ziyuan Guo Development. 2022;149(22):dev201395. doi: 10.1242/dev.201395 https://doi.org/10.1242/dev.201395 Library Collection(s) Reviews and perspectives Download Citation BibTeX EndNote X3 XML EndNote 7 XML EndNote tagged Marc …
A Pathway to Personalizing Therapy for Metastases Using Liver-on-a-Chip Platforms
ReferenceA. S. Khazali , A. M. Clark , A. Wells Stem Cell Reviews and Reports. 2017;13(3):364-380. doi: 10.1007/s12015-017-9735-3 Metastasis accounts for most cancer-related deaths. The majority of solid cancers, including those of the breast, colorectum, prostate …
A multi-organ chip with matured tissue niches linked by vascular flow
ReferenceKacey Ronaldson-Bouchard , Diogo Teles , Keith Yeager , Daniel Naveed Tavakol , Yimu Zhao , Alan Chramiec , Somnath Tagore , Max Summers , Sophia Stylianos , Manuel Tamargo , Busub Marcus Lee , Susan P. Halligan , Erbil Hasan Abaci , Zongyou Guo , Joanna …