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Better science for safer medicines: the human imperative
ReferenceKathy Archibald , Katya Tsaioun , J. Gerry Kenna , Pandora Pound Journal of the Royal Society of Medicine. 2018;111(12):433-438. doi: 10.1177/0141076818812783 https://journals.sagepub.com/doi/10.1177/0141076818812783 Keywords Drug Discovery Drug Industry …
Can animal data translate to innovations necessary for a new era of patient-centred and individualised healthcare? Bias in preclinical animal research
ReferenceSusan Bridgwood Green BMC Medical Ethics. 2015;16:53. doi: 10.1186/s12910-015-0043-7 BACKGROUND: The public and healthcare workers have a high expectation of animal research which they perceive as necessary to predict the safety and efficacy of drugs …
Capture, release and culture of circulating tumor cells from pancreatic cancer patients using an enhanced mixing chip
ReferenceWeian Sheng , Olorunseun O. Ogunwobi , Tao Chen , Jinling Zhang , Thomas J. George , Chen Liu , Z. Hugh Fan Lab on a Chip. 2014;14(1):89-98. doi: 10.1039/c3lc51017d Circulating tumor cells (CTCs) from peripheral blood hold important information for cancer …
Cerebral organoids containing an AUTS2 missense variant model microcephaly
ReferenceSummer R. Fair , Wesley Schwind , Dominic L. Julian , Alecia Biel , Gongbo Guo , Ryan Rutherford , Swetha Ramadesikan , Jesse Westfall , Katherine E. Miller , Meisam Naeimi Kararoudi , Scott E. Hickey , Theresa Mihalic Mosher , Kim L. McBride , Reid …
Conventional laboratory housing increases morbidity and mortality in research rodents: results of a meta-analysis
ReferenceJessica Cait , Alissa Cait , R. Wilder Scott , Charlotte B. Winder , Georgia J. Mason BMC Biology. 2022;20(1):15. doi: 10.1186/s12915-021-01184-0 BACKGROUND: Over 120 million mice and rats are used annually in research, conventionally housed in …
Critical evaluation of challenges and future use of animals in experimentation for biomedical research
ReferenceVijay Pal Singh , Kunal Pratap , Juhi Sinha , Koundinya Desiraju , Devika Bahal , Ritushree Kukreti International Journal of Immunopathology and Pharmacology. 2016;29(4):551-561. doi: 10.1177/0394632016671728 Animal experiments that are conducted …
Effects of Rodent Thermoregulation on Animal Models in the Research Environment
ReferenceF. Claire Hankenson , James O. Marx , Christopher J. Gordon , John M. David Comparative Medicine. 2018;68(6):425-438. doi: 10.30802/AALAS-CM-18-000049 To best promote animal wellbeing and the efficacy of biomedical models, scientific, husbandry, and …
Engineering functional 3-dimensional patient-derived endocrine organoids for broad multiplatform applications
ReferenceNaira Baregamian , Konjeti R. Sekhar , Evan S. Krystofiak , Maria Vinogradova , Giju Thomas , Emmanuel Mannoh , Carmen C. Solórzano , Colleen M. Kiernan , Anita Mahadevan-Jansen , Naji Abumrad , Michael L. Freeman , Vivian L. Weiss , Jeffrey C. Rathmell , …
EURL ECVAM Literature Review Series on Advanced Non-Animal Models for Respiratory Diseases, Breast Cancer and Neurodegenerative Disorders
ReferenceLaura Gribaldo , Adelaide Dura Animals (Basel). 2022;12(17):2180. doi: 10.3390/ani12172180 In vivo models are used in biomedical research to reproduce human disease and develop new drugs. However, they do not mimic the disease as it occurs in humans, and …
From microfluidics to microphysiological systems: Past, present, and future
ReferenceMarÃa Virumbrales-Muñoz , Jose M. Ayuso Organs-on-a-Chip. 2022;4:100015. doi: 10.1016/j.ooc.2022.100015 For over a decade, we have seen significant strides in the microfluidics field that have led to the concept of microphysiological systems. These …