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An evaluation framework for new approach methodologies (NAMs) for human health safety assessment
ReferenceStanley T. Parish , Michael Aschner , Warren Casey , Marco Corvaro , Michelle R. Embry , Suzanne Fitzpatrick , Darren Kidd , Nicole C. Kleinstreuer , Beatriz Silva Lima , Raja S. Settivari , Douglas C. Wolf , Daiju Yamazaki , Alan Boobis Regulatory …
A human-derived neurovascular unit in vitro model to study the effects of cellular cross-talk and soluble factors on barrier integrity
ReferenceChiara Barberio , Aimee Withers , Yash Mishra , Pierre-Olivier Couraud , Ignacio A. Romero , Babette Weksler , RóisÃn M. Owens Frontiers in Cellular Neuroscience. 2022;16:1065193. doi: 10.3389/fncel.2022.1065193 The blood-brain barrier (BBB) restricts …
A microengineered Brain-Chip to model neuroinflammation in humans
ReferenceIosif Pediaditakis , Konstantia R. Kodella , Dimitris V. Manatakis , Christopher Y. Le , Sonalee Barthakur , Alexander Sorets , Achille Gravanis , Lorna Ewart , Lee L. Rubin , Elias S. Manolakos , Christopher D. Hinojosa , Katia Karalis iScience. …
A microfluidic model of human vascularized breast cancer metastasis to bone for the study of neutrophil-cancer cell interactions
ReferenceMartina Crippa , Giuseppe Talò , Anaïs Lamouline , Sara Bolis , Chiara Arrigoni , Simone Bersini , Matteo Moretti Materials Today. Bio. 2022;17:100460. doi: 10.1016/j.mtbio.2022.100460 The organ-specific metastatization of breast cancer to bone is driven …
A neurovascular-unit-on-a-chip for the evaluation of the restorative potential of stem cell therapies for ischaemic stroke
ReferenceZhonglin Lyu , Jon Park , Kwang-Min Kim , Hye-Jin Jin , Haodi Wu , Jayakumar Rajadas , Deok-Ho Kim , Gary K. Steinberg , Wonjae Lee Nature Biomedical Engineering. 2021;5(8):847-863. doi: 10.1038/s41551-021-00744-7 The therapeutic efficacy of stem cells …
Advanced Development of Primary Pancreatic Organoid Tumor Models for High-Throughput Phenotypic Drug Screening
ReferenceShurong Hou , Hervé Tiriac , Banu Priya Sridharan , Louis Scampavia , Franck Madoux , Jan Seldin , Glauco R. Souza , Donald Watson , David Tuveson , Timothy P. Spicer SLAS discovery: advancing life sciences R & D. 2018;23(6):574-584. doi: …
Ancestry matters: Building inclusivity into preclinical study design
ReferenceSophie Zaaijer , Amanda Capes-Davis Cell. 2021;184(10):2525-2531. doi: 10.1016/j.cell.2021.03.041 Human cell lines (CLs) are key assets for biomedicine but lack ancestral diversity. Here, we explore why genetic diversity among cell-based models is …
Are Animal Models Needed to Discover, Develop and Test Pharmaceutical Drugs for Humans in the 21st Century?
ReferencePandora Pound Animals (Basel). 2020;10(12):2455. doi: 10.3390/ani10122455 Despite many decades of research, much of which has focused on studies in animals, we humans continue to suffer from multiple diseases for which there are no cures or treatments …
Are animal models predictive for humans?
ReferenceNiall Shanks , Ray Greek , Jean Greek Philosophy, ethics, and humanities in medicine: PEHM. 2009;4:2. doi: 10.1186/1747-5341-4-2 It is one of the central aims of the philosophy of science to elucidate the meanings of scientific terms and also to think …
Awareness and knowledge of manuscript writing and research integrity: A cross sectional survey among graduate students
ReferenceFadia Mayyas , Karem Alzoubi Heliyon. 2022;8(11):e11447. doi: 10.1016/j.heliyon.2022.e11447 Graduate students face a variety of barriers when writing manuscripts. The major barrier is inadequate writing experience and training. We aimed to evaluate the …