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Engineering viral genomics and nano-liposomes in microfluidic platforms for patient-specific analysis of SARS-CoV-2 variants
ReferenceSandro Satta , Fahimeh Shahabipour , Wei Gao , Steven R. Lentz , Stanley Perlman , Nureddin Ashammakhi , Tzung Hsiai Theranostics. 2022;12(10):4779-4790. doi: 10.7150/thno.72339 New variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) …
Application of lung microphysiological systems to COVID-19 modeling and drug discovery: a review
ReferenceArgus M. Sun , Tyler Hoffman , Bao Q. Luu , Nureddin Ashammakhi , Song Li Bio-Design and Manufacturing. 2021;4(4):757-775. doi: 10.1007/s42242-021-00136-5 There is a pressing need for effective therapeutics for coronavirus disease 2019 (COVID-19), the …
Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development
ReferenceKacey Ronaldson-Bouchard , Gordana Vunjak-Novakovic Cell Stem Cell. 2018;22(3):310-324. doi: 10.1016/j.stem.2018.02.011 Organs-on-a-chip (OOCs) are miniature tissues and organs grown in vitro that enable modeling of human physiology and disease. The …
Organoids-on-a-chip
ReferenceSunghee Estelle Park , Andrei Georgescu , Dongeun Huh Science (New York, N.Y.). 2019;364(6444):960-965. doi: 10.1126/science.aaw7894 Recent studies have demonstrated an array of stem cell-derived, self-organizing miniature organs, termed organoids, that …
4.2 million and counting… The animal toll for REACH systemic toxicity studies
ReferenceJean Knight , Thomas Hartung , Costanza Rovida ALTEX - Alternatives to animal experimentation. 2023;40(3):389-407. doi: 10.14573/altex.2303201 The EU’s chemicals regulation, REACH, requires that most chemicals in the EU be evaluated for human health and …
What Is the Predictive Value of Animal Models for Vaccine Efficacy in Humans? The Importance of Bridging Studies and Species-Independent Correlates of Protection
ReferenceHana Golding , Surender Khurana , Marina Zaitseva Cold Spring Harbor Perspectives in Biology. 2018;10(4):a028902. doi: 10.1101/cshperspect.a028902 Animal models have played a pivotal role in all stages of vaccine development. Their predictive value for …
Can prospective systematic reviews of animal studies improve clinical translation?
ReferencePandora Pound , Merel Ritskes-Hoitinga Journal of Translational Medicine. 2020;18:15. doi: 10.1186/s12967-019-02205-x Systematic reviews are powerful tools with the potential to generate high quality evidence. Their application to animal studies has been …
A village in a dish model system for population-scale hiPSC studies
ReferenceDrew R. Neavin , Angela M. Steinmann , Nona Farbehi , Han Sheng Chiu , Maciej S. Daniszewski , Himanshi Arora , Yasmin Bermudez , Cátia Moutinho , Chia-Ling Chan , Monique Bax , Mubarika Tyebally , Vikkitharan Gnanasambandapillai , Chuan E. Lam , Uyen …
When Is Something an Alternative? A General Account Applied to Animal-Free Alternatives to Animal Research
ReferenceKoen Kramer Cambridge Quarterly of Healthcare Ethics. 2023;33(1):89-101. doi: 10.1017/S0963180123000300 The first “R” from animal research ethics prescribes the replacement of animal experiments with animal-free alternatives. However, the question of when …
A framework for establishing scientific confidence in new approach methodologies
ReferenceAnna J. van der Zalm , João Barroso , Patience Browne , Warren Casey , John Gordon , Tala R. Henry , Nicole C. Kleinstreuer , Anna B. Lowit , Monique Perron , Amy J. Clippinger Archives of Toxicology. 2022;96:2865-2879. doi: 10.1007/s00204-022-03365-4 …