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An open-source screening platform accelerates discovery of drug combinations
ReferenceWilliam C. Wright , Min Pan , Gregory A. Phelps , Jonathan Low , Duane Currier , Ankita Sanjali , Marlon Trotter , Jihye Hwang , Richard H. Chapple , Xueying Liu , Declan Bennett , Yinwen Zhang , Richard E. Lee , Taosheng Chen , Paul Geeleher Nature …
Use of new approach methodologies (NAMs) in epilepsy research and seizure risk assessment
ReferenceRuth A. Roberts , Mamta Behl , Helena T. Hogberg , Eduardo Dunayevich , Michael Morton , Kimberly L. Rockley , Abigail L. Walker , Jennifer B. Pierson Drug Discovery Today. 2025;31(1):104569. doi: 10.1016/j.drudis.2025.104569 Seizures are the hallmark of …
Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges
ReferenceDaisong Wang , Remi Villenave , Nadine Stokar-Regenscheit , Hans Clevers Nature Reviews Drug Discovery. 2025:1-23. doi: 10.1038/s41573-025-01317-y Organoids are 3D structures derived from stem cells that recapitulate key architectural and functional …
High-throughput bioprinting of spheroids for scalable tissue fabrication
ReferenceMyoung Hwan Kim , Yogendra Pratap Singh , Nazmiye Celik , Miji Yeo , Elias Rizk , Daniel J. Hayes , Ibrahim T. Ozbolat Nature Communications. 2024;15(1):10083. doi: 10.1038/s41467-024-54504-7 Tissue biofabrication mimicking organ-specific architecture and …
A tumor-on-a-chip for in vitro study of CAR-T cell immunotherapy in solid tumors
ReferenceHaijiao Liu , Estela Noguera-Ortega , Xuanqi Dong , Won Dong Lee , Jeehan Chang , Sezin Aday Aydin , Yumei Li , Yonghee Shin , Xinyi Shi , Maria Liousia , Marina C. Martinez , Joshua J. Brotman , Soyeon Kim , Zeyu Chen , Anni Wang , Zirui Ou , Jungwook …
CRISPR screens in human neural organoids and assembloids
ReferenceXiangling Meng , Noah Reis , Michael C. Bassik , Sergiu P. Pașca Nature Protocols. 2025:1-21. doi: 10.1038/s41596-025-01299-6 Studying the molecular mechanisms underlying the assembly of the human nervous system remains a significant challenge. The …
Confidence in new approach methods (NAMs): Ensuring reproducibility, operationalising context-of-use and alignment with decision-making needs
ReferenceMiriam N. Jacobs , Heli M. Hollnagel , Karma Fussel , Giel Hendriks , Ioanna Katsiadaki , Susanne N. Kolle , Morné E. van der Mescht , Andreas Natsch , Hans Raabe , Amanda Ulrey , Robert Landsiedel Regulatory Toxicology and Pharmacology. 2026;166:106016. …
Cognitive Dissonance in Laboratory Animal Medicine and Implications for Animal Welfare
ReferenceRobyn M Engel , Carrie C Silver , Christin L Veeder , Ron E Banks Journal of the American Association for Laboratory Animal Science : JAALAS. 2020;59(2):132-138. doi: 10.30802/AALAS-JAALAS-19-000073 People experience cognitive dissonance when they …
Modeling human embryo implantation in vitro
ReferenceMatteo A. Molè , Sarah Elderkin , Irene Zorzan , Christopher Penfold , Nicole Horsley , Alexandra Pokhilko , Max Polanek , Andrea Palomar , Molika Sinha , Yang Wang , Alicia Quiñonero , Charalampos Androulidakis , Richard Acton , Kathryn Balmanno , …
A human lung organoid platform for studying radiation-induced pulmonary fibrosis and antifibrotic drug screening
ReferenceHae-Ran Park , Yeongkag Kwon , Hyun Jung Ji , Sun-Young Kim , Min-Kyu Kim , Ki Bum Ahn , Ho Seong Seo Scientific Reports. 2025. doi: 10.1038/s41598-025-31582-1 Radiation-induced pulmonary injury and fibrosis (RIPI/RIPF) is a major complication following …