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Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems
ReferenceChunhui Tian , Zheng Ao , Jonas Cerneckis , Hongwei Cai , Lei Chen , Hengyao Niu , Kazuo Takayama , Jungsu Kim , Yanhong Shi , Mingxia Gu , Takahisa Kanekiyo , Feng Guo Science Advances. 2025;11(34):eadu2708. doi: 10.1126/sciadv.adu2708 Increasing …
A bioprinted model of pregnant human uterine myometrium
ReferenceCraig Ulrich , Korrina Siddiqui , Lexa K. Baldwin , Weijian Hua , Jacob K. Kuklok , Jada J. Okaikoi , Lauren L. Parker , Juli Petereit , Dave R. Quilici , Grace M. Silva , Anutr Sivakoses , Jiavanna S. Wong-Fortunato , Rebekah J. Woolsey , Adrian West , …
Vascular Organoids Derived from Capillary malformation-induced Pluripotent Stem Cells Exhibit Disease-Relevant Phenotypes
ReferenceVi Nguyen , Anna Harper , Mackenzie Azuero , Isabella Castellanos , Siwuxie He , Marcelo L. Hochman , Camilla F. Wenceslau , Dong-bao Chen , Anil G. Jegga , Yunguan Wang , Daping Fan , J. Stuart Nelson , Wenbin Tan Stem Cell Reviews and Reports. 2025. …
Variability vs. phenotype: Multimodal analysis of Dravet syndrome brain organoids powered by deep learning
ReferenceIsabel Turpin-Moreno , Adriana Modrego , Andrea MartÃ-Sarrias , Laura GarcÃa-González , Alba Ortega-Gasco , Anna-Christina Haeb , Ruth Pareja , Jordi Soriano , Núria Ruiz , Irene Peñuelas-Haro , Elisa Espinet , Arcadi Navarro , Daniel Tornero , Oscar Lao …
A microfluidic platform for culturing and high-content imaging of adult stem cell-derived organoids
ReferenceKhashayar Moshksayan , Rishika Khanna , Berk Camli , Zeynep Nevra Yakay , Anirudha Harihara , Christopher Zdyrski , Sudip Mondal , Evan Hegarty , Jonathan P. Mochel , Karin Allenspach , Adela Ben-Yakar Scientific Reports. 2025;15(1):40162. doi: …
Why 90% of clinical drug development fails and how to improve it?
ReferenceDuxin Sun , Wei Gao , Hongxiang Hu , Simon Zhou Acta Pharmaceutica Sinica B. 2022;12(7):3049-3062. doi: 10.1016/j.apsb.2022.02.002 Ninety percent of clinical drug development fails despite implementation of many successful strategies, which raised the …
V-Cornea: A computational model of corneal epithelium homeostasis, injury, and recovery
ReferenceJoel Vanin , Michael Getz , Catherine Mahony , Thomas B. Knudsen , James A. Glazier PLOS Computational Biology. ;21(12):e1013410. doi: 10.1371/journal.pcbi.1013410 Purpose To develop a computational model that addresses limitations in current ocular …
NAMazing: The importance of being earnest - a 2025 cross-Atlantic turning point in phasing out animal testing
ReferenceLove Hansell , Thomas Hartung NAM Journal. 2025:100071. doi: 10.1016/j.namjnl.2025.100071 2025 marked an unprecedented synchrony of political initiatives to reduce and replace animal testing across the United States, United Kingdom, and European Union. …
The Promise of Animal Testing Alternatives at the U.S. Food and Drug Administration and National Institutes of Health
ReferenceRicardo Scheufen Tieghi , Tracy Beth Høeg , Martin A. Makary , Nicole Kleinstreuer NEJM AI. 2025;3(1):AIpc2500587. doi: 10.1056/AIpc2500587 https://ai.nejm.org/doi/full/10.1056/AIpc2500587 Library Collection(s) Ethics, policy, and legislation Download …
Vascularized human brain organoids as a model of the brain–peripheral axis in HIV-1 neuropathogenesis
ReferenceSathish Selvam , Roberta S. Dos Reis , Marc C. E. Wagner , Rishi Krishnakumar , Kamyar Keshavarz , Mo R. Ebrahimkhani , Velpandi Ayyavoo Scientific Reports. 2026. doi: 10.1038/s41598-025-33940-5 Advances in stem cell biology and tissue engineering have …