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Immunocompetent cancer-on-chip models to assess immuno-oncology therapy
ReferenceTengku Ibrahim Maulana , Elena Kromidas , Lars Wallstabe , Madalena Cipriano , Miriam Alb , Cécile Zaupa , Michael Hudecek , Birgit Fogal , Peter Loskill Advanced Drug Delivery Reviews. 2021;173:281-305. doi: 10.1016/j.addr.2021.03.015 The advances in …
WAT-on-a-chip integrating human mature white adipocytes for mechanistic research and pharmaceutical applications
ReferenceJulia Rogal , Carina Binder , Elena Kromidas , Julia Roosz , Christopher Probst , Stefan Schneider , Katja Schenke-Layland , Peter Loskill Scientific Reports. 2020;10(1):6666. doi: 10.1038/s41598-020-63710-4 Obesity and its numerous adverse health …
3D In Vitro Models of Breast Cancer: Current Challenges and Future Prospects Toward Recapitulating the Microenvironment and Mimicking Key Processes
ReferenceKyndra S. Higgins , Ah Joung Yu , Cheryl T. Gomillion Advanced Biology. 2025;9(11):e00846. doi: 10.1002/adbi.202400846 Each year, ≈1.6 million women are diagnosed with breast cancer worldwide. Of these cases, 0.5 million result in death, with over 90% of …
Whole cervix imaging of collagen, muscle, and cellularity in term and preterm pregnancy
ReferenceWenjie Wu , Zhexian Sun , Hansong Gao , Yuan Nan , Stephanie Pizzella , Haonan Xu , Josephine Lau , Yiqi Lin , Hui Wang , Pamela K. Woodard , Hannah R. Krigman , Qing Wang , Yong Wang Nature Communications. 2024;15(1):5942. doi: 10.1038/s41467-024-48680-9 …
Identification of cervical cancer stem cells using single-cell transcriptomes of normal cervix, cervical premalignant lesions, and cervical cancer
ReferenceTao Zhang , Liang Zhuang , Munawaer Muaibati , Dan Wang , Abuduyilimu Abasi , Qing Tong , Ding Ma , Lei Jin , Xiaoyuan Huang eBioMedicine. 2023;92. doi: 10.1016/j.ebiom.2023.104612 …
Investigating the delivery of PD-L1-targeted immunoliposomes in a dynamic cervical cancer-on-a-chip model
ReferenceSeth-Frerich Fobian , Mohamadreza Amin , Andrea Sacchetti , Arlene L. Oei , Timo L. M. ten Hagen Journal of Controlled Release. 2025;379:236-250. doi: 10.1016/j.jconrel.2025.01.014 The recent approval of pembrolizumab in recurrent or metastatic cervical …
Cervix chip mimicking cervical microenvironment for quantifying sperm locomotion
ReferenceSai-Xi Yu , Yanan Liu , Yi Wu , Hao Luo , Rufei Huang , Ya-Jun Wang , Xuemei Wang , Hai Gao , Huijuan Shi , Guangyin Jing , Yan-Jun Liu Biosensors and Bioelectronics. 2022;204:114040. doi: 10.1016/j.bios.2022.114040 As the gate for sperm swimming into the …
Cervical mucus in linked human Cervix and Vagina Chips modulates vaginal dysbiosis
ReferenceOla Gutzeit , Aakanksha Gulati , Zohreh Izadifar , Anna Stejskalova , Hassan Rhbiny , Justin Cotton , Bogdan Budnik , Sanjid Shahriar , Girija Goyal , Abidemi Junaid , Donald E. Ingber npj Women's Health. 2025;3(1):5. doi: 10.1038/s44294-025-00054-2 This …
Phase II Trials in Drug Development and Adaptive Trial Design
ReferenceGail A. Van Norman JACC: Basic to Translational Science. 2019;4(3):428-437. doi: 10.1016/j.jacbts.2019.02.005 Phase II clinical studies represent a critical point in determining drug costs, and phase II is a poor predictor of drug success: >30% of drugs …
Drugs, Devices, and the FDA: Part 1: An Overview of Approval Processes for Drugs
ReferenceGail A. Van Norman JACC: Basic to Translational Science. 2016;1(3):170-179. doi: 10.1016/j.jacbts.2016.03.002 Over the last 150 years, the U.S. Food and Drug Administration (FDA) has evolved from a small division of the U.S. Patent Office to 1 of the …