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Nasal microbionts differentially colonize and elicit cytokines in human nasal epithelial organoids
ReferenceAndrea I. Boyd , Leah A. Kafer , Isabel F. Escapa , Amal Kambal , Hira Tariq , Susan G. Hilsenbeck , Hoa Nguyen-Phuc , Anubama Rajan , Joshua M. Lensmire , Kathryn A. Patras , Pedro A. Piedra , Sarah E. Blutt , Katherine P. Lemon mSphere. …
A 3D in vitro model for studying human implantation and implantation failure
ReferenceQian Li , Yang Yuan , Wentao Zhao , Yuanjun Li , Juanzi Shi , Yu Xiu , Mi Han , Yan Han , Junmei Zhang , Shuhan Cheng , Xin Qi , Xizhuang Sun , Tan Jia , Jiaqi Xing , Siwei Deng , Xiaodi Yan , Seiya Oura , Hongfei Li , Ying Sun , Huiyao Yuan , Xiaohong Ma …
Biomaterial-minimalistic photoactivated bioprinting of cell-dense tissues
ReferenceMian Wang , Wanlu Li , Jin Hao , Ling Cai , Xuan Mei , Regina Sanchez Flores , Penélope Cerón Castillo , Carlos Ezio Garciamendez-Mijares , Xuan Mu , Xiao Kuang , Xianbin Yu , Jugal Kishore Sahoo , Guosheng Tang , Zeyu Luo , Guillermo Wells , Zhongmin Liu …
Modeling early gastrulation in human blastoids with DNA methylation patterns of natural blastocysts
ReferenceHan Xie , Chenrui An , Bing Bai , Jiajia Luo , Nianqin Sun , Baiquan Ci , Long Jin , Peiting Mo , Yawen Lu , Ke Zhong , Yang Yu , Tao Tan , Rong Li , Yong Fan Cell Stem Cell. 2025;32(3):409-425.e8. doi: 10.1016/j.stem.2024.12.010 …
Beyond the amyloid hypothesis: leveraging human-centered complex in vitro models to decode Alzheimer’s disease etiology
ReferenceMatthew Price , Francesca Pistollato Frontiers in Toxicology. 2026;7. doi: 10.3389/ftox.2025.1753572 Alzheimer’s disease (AD) is a complex neurodegenerative condition and the leading cause of dementia worldwide. Treatments that safely and effectively …
Protocol for modeling the repair of intestinal damage by co-culturing mesenchymal stromal/stem cells and intestinal organoids
ReferenceKari-Pekka Skarp , Bahar Yetkin-Arik , Suze A. Jansen , Caroline A. Lindemans , Magdalena J. Lorenowicz STAR protocols. 2025;7(1):104292. doi: 10.1016/j.xpro.2025.104292 Mesenchymal stem/stromal cells (MSCs) are known for their regenerative properties. …
Mesenchymal stromal/stem cells promote intestinal epithelium regeneration after chemotherapy-induced damage
ReferenceB. Yetkin-Arik , S. A. Jansen , S. Varderidou-Minasian , B. Westendorp , K.-P. Skarp , M. Altelaar , C. A. Lindemans , M. J. Lorenowicz Stem Cell Research & Therapy. 2024;15(1):125. doi: 10.1186/s13287-024-03738-9 Allogeneic hematopoietic stem cell …
Automating Vascular Biology: An End-to-End Automated Workflow for High-Throughput Blood Vessel-on-a-Chip Production and Multi-Site Validation
ReferenceDawn S. Y. Lin , Hanieh Mohammad Hashemi , Kimia Asadi Jozani , Anushree Chakravarty , Sonya Kouthouridis , Jessica Bonanno , Nicky Anvari , Shravanthi Rajasekar , Feng Zhang , Richard Y. Cheng , Narendra Kumar Singh , Luis Miguel Medina , Marc Durante , …
Advancing the frontier of rare disease modeling: a critical appraisal of in silico technologies
ReferenceFrancesca Pistollato , Fabia Furtmann , Lindsay J. Marshall , Surat Parvatam , Jan Turner , Flora Tshinanu Musuamba , Giulia Russo , Francesco Pappalardo npj Digital Medicine. 2025;8(1):676. doi: 10.1038/s41746-025-02068-1 Rare diseases affect over 300 …
Lymphatics-on-a-chip microphysiological system: engineering lymphatic structure and function in vitro
ReferenceYansong Peng , Esak Lee Lab on a Chip. 2026. doi: 10.1039/D5LC00875A The lymphatic system—integral to fluid balance, immune surveillance, and lipid absorption—is frequently overlooked despite its vital roles. Traditional research modalities, including …