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How animal ethics committees make decisions – a scoping review of empirical studies
ReferenceAoife Milford , Eva De Clercq , Edwin Louis-Maerten , Lester D. Geneviève , Bernice S. Elger PLOS ONE. ;20(3):e0318570. doi: 10.1371/journal.pone.0318570 Objectives The aim of the scoping review is to explore the decision-making process for the evaluation …
A mental-health crisis plagues PhDs — these evidence-led initiatives offer help
ReferenceFred Schwaller Nature. 2025. doi: 10.1038/d41586-025-01083-2 Communities of researchers worldwide are taking on the toxic research cultures that drive poor psychological health among academics. https://www.nature.com/articles/d41586-025-01083-2 Keywords …
Clinical development times for innovative drugs
ReferenceDean G. Brown , Heike J. Wobst , Abhijeet Kapoor , Leslie A. Kenna , Noel Southall Nature Reviews Drug Discovery. 2021;21(11):793-794. doi: 10.1038/d41573-021-00190-9 Discover the world’s best science and medicine | Nature.com …
Human induced pluripotent stem cell-derived cardiomyocytes and their use in a cardiac organ-on-a-chip to assay electrophysiology, calcium and contractility
ReferenceM. Iveth Garcia , Keri Dame , Verena Charwat , Brian A. Siemons , Henrik Finsberg , Bhavya Bhardwaj , Ryosuke Yokosawa , Ishan Goswami , Dylan Bruckner , Samuel T. Wall , Kevin A. Ford , Kevin E. Healy , Alexandre J. S. Ribeiro Nature Protocols. …
Human stem cell-based retina on chip as new translational model for validation of AAV retinal gene therapy vectors
ReferenceKevin Achberger , Madalena Cipriano , Matthias J. Düchs , Christian Schön , Stefan Michelfelder , Birgit Stierstorfer , Thorsten Lamla , Stefan G. Kauschke , Johanna Chuchuy , Julia Roosz , Lena Mesch , Virginia Cora , Selin Pars , Natalia Pashkovskaia , …
Human motor units in microfluidic devices are impaired by FUS mutations and improved by HDAC6 inhibition
ReferenceKatarina Stoklund Dittlau , Emily N. Krasnow , Laura Fumagalli , Tijs Vandoorne , Pieter Baatsen , Axelle Kerstens , Giorgia Giacomazzi , Benjamin Pavie , Elisabeth Rossaert , Jimmy Beckers , Maurilio Sampaolesi , Philip Van Damme , Ludo Van Den Bosch …
Single cell sequencing analysis of respiratory syncytial virus–infected pediatric and adult human nose organoids reveals age differences, proliferative diversity and identifies novel cellular tropism
ReferenceAnubama Rajan , Divya Nagaraj , Carolyn Bomidi , Gina M. Aloisio , Ashley M. Murray , Emily M. Schultz , Amal Kambal , Mary K. Estes , Erin Nicholson , Vasanthi Avadhanula , Sarah E. Blutt , Pedro A. Piedra Journal of Infection. 2025;91(4). doi: …
Spheromatrix: a paper-based platform for scalable 3D tumor model generation, cryopreservation, and high-throughput drug assessment
ReferenceAyoub Glia , Muhammedin Deliorman , Pavithra Sukumar , Mohammad A. Qasaimeh Microsystems & Nanoengineering. 2025;11(1):219. doi: 10.1038/s41378-025-01077-0 Three-dimensional in vitro tumor models are increasingly recognized for their value in preclinical …
Large-scale drug screening in iPSC-derived motor neurons from sporadic ALS patients identifies a potential combinatorial therapy
ReferenceChristopher R. Bye , Elizabeth Qian , Katherine Lim , Maciej Daniszewski , Fleur C. Garton , Bảo C. Trần-Lê , Helena H. Liang , Tian Lin , John G. Lock , Duncan E. Crombie , Steven Morgan , Yi Hu , Samantha K. Barton , Lucy M. Palmer , Elvan Djouma , …
How to Give Ethical Input on Animal Research Transitions: Ideal and Nonideal Theory
ReferenceNico Dario Müller Journal of Agricultural and Environmental Ethics. 2025;39(1):2. doi: 10.1007/s10806-025-09965-1 Research that harms animals raises the question of whether and how science should be transformed over time. To helpfully address this issue, …