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Bioprinting 101: Design, Fabrication, and Evaluation of Cell-Laden 3D Bioprinted Scaffolds
ReferenceKaivalya A. Deo , Kanwar Abhay Singh , Charles W. Peak , Daniel L. Alge , Akhilesh K. Gaharwar Tissue Engineering. Part A. 2020;26(5-6):318-338. doi: 10.1089/ten.tea.2019.0298 3D bioprinting is an additive manufacturing technique that recapitulates the …
Upscaling: efficient generation of human lung organoids from induced pluripotent stem cells using a stirring bioreactor
ReferenceBettina Budeus , Chiara Kroepel , Zehra Fatma Sevindik , Luca Fabian Buttler , Diana Klein Frontiers in Bioengineering and Biotechnology. 2025;13. doi: 10.3389/fbioe.2025.1684315 IntroductionHuman induced pluripotent stem cells (iPSCs) can be successfully …
Industrial and agricultural chemicals exhibit antimicrobial activity against human gut bacteria in vitro
ReferenceIndra Roux , Anna E. Lindell , Anne Grießhammer , Tom Smith , Shagun Krishna , Rui Guan , Deniz Rad , Luisa Faria , Sonja Blasche , Kaustubh R. Patil , Nicole C. Kleinstreuer , Lisa Maier , Stephan Kamrad , Kiran R. Patil Nature Microbiology. …
Preconfigured neuronal firing sequences in human brain organoids
ReferenceTjitse van der Molen , Alex Spaeth , Mattia Chini , Sebastian Hernandez , Gregory A. Kaurala , Hunter E. Schweiger , Cole Duncan , Sawyer McKenna , Jinghui Geng , Max Lim , Julian Bartram , Tobias Gänswein , Aditya Dendukuri , Zongren Zhang , Jesus …
Human myelinated brain organoids with integrated microglia as a model for myelin repair and remyelinating therapies
ReferenceSimona Lange , Martin Ebeling , Athéna Loye , Florian Wanke , Juliane Siebourg-Polster , Tania J. J. Sudharshan , Franziska Völlmy , Jakub Kralik , Bérengère Vidal , Kerstin Hahn , Lynette C. Foo , Jan Hoeber Science Translational Medicine. …
Engineered 3D immuno-glial-neurovascular human miBrain model
ReferenceAlice E. Stanton , Adele Bubnys , Emre Agbas , Benjamin James , Dong Shin Park , Alan Jiang , Rebecca L. Pinals , Liwang Liu , Nhat Truong , Anjanet Loon , Colin Staab , Oyku Cerit , Hsin-Lan Wen , David Mankus , Margaret E. Bisher , Abigail K. R. …
Advancements in the in vitro culture of human pluripotent stem cells: progress, challenges, and future directions: comprehensive review
ReferenceNiraj Chaudhary , Luis G. Villa-Diaz Frontiers in Toxicology. 2025;7. doi: 10.3389/ftox.2025.1667573 The advancement of human pluripotent stem cell (hPSC) culture systems has revolutionized the landscape of preclinical drug discovery and toxicological …
Proliferation and metabolic activity of the Atlantic sturgeon cell line AOXlar7y under short-term serum-reduced conditions, and the effect of stimulation with growth factors and cytokines
ReferenceValeria Di Leonardo , Julia Brenmoehl , Heike Wanka , Bianka Grunow Frontiers in Toxicology. 2025;7. doi: 10.3389/ftox.2025.1636776 IntroductionFish cell lines represent a powerful tool for studying the biology and toxicology of aquatic species in …
Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip
ReferenceHuub J. Weener , Heleen H. T. Middelkamp , Andries D. van der Meer Frontiers in Toxicology. 2024;6. doi: 10.3389/ftox.2024.1513002 Microphysiological systems (MPS) and Organs-on-Chips (OoCs) hold significant potential for replicating complex human …
A single-chain derivative of an integrin-activating antibody potentiates organoid growth in Matrigel and collagen hydrogels
ReferenceWim B. M. de Lau , Joost J. A. P. M. Wijnakker , Gijs J. F. van Son , Daniel Krueger , Daisong Wang , Matthijs S. Abendroth , Robin Schreurs , Claudia Y. Janda , Fenna L. H. van Rijt , Benjamin J. P. Chalopin , Emma Bokobza , Johan H. van Es , Timothy A. …