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A probabilistic histological atlas of the human brain for MRI segmentation
ReferenceAdrià Casamitjana , Matteo Mancini , Eleanor Robinson , Loïc Peter , Roberto Annunziata , Juri Althonayan , Shauna Crampsie , Emily Blackburn , Benjamin Billot , Alessia Atzeni , Oula Puonti , Yaël Balbastre , Peter Schmidt , James Hughes , Jean C. …
Precision Medicine and the FDA Modernization Act 2.0: Catalyzing Innovation in Cardiovascular Therapy
ReferenceDominic E. Fullenkamp , Lisa D. Wilsbacher , Hanna J. Tadros , Pankaj Arora , Thomas P. Cappola Circulation: Genomic and Precision Medicine. doi: 10.1161/CIRCGEN.125.005487 Animal models are an essential part of preclinical research, serving to protect …
Antisense oligonucleotide therapeutic approach for Timothy syndrome
ReferenceXiaoyu Chen , Fikri Birey , Min-Yin Li , Omer Revah , Rebecca Levy , Mayuri Vijay Thete , Noah Reis , Konstantin Kaganovsky , Massimo Onesto , Noriaki Sakai , Zuzana Hudacova , Jin Hao , Xiangling Meng , Seiji Nishino , John Huguenard , Sergiu P. Pașca …
Human organoids as 3D in vitro platforms for drug discovery: opportunities and challenges
ReferenceDaisong Wang , Remi Villenave , Nadine Stokar-Regenscheit , Hans Clevers Nature Reviews Drug Discovery. 2025:1-23. doi: 10.1038/s41573-025-01317-y Organoids are 3D structures derived from stem cells that recapitulate key architectural and functional …
Human Cervix Chip: A Preclinical Model for Studying the Role of the Cervical Mucosa and Microbiome in Female Reproductive Health
ReferenceZohreh Izadifar , Anna Stejskalova , Aakanksha Gulati , Ola Gutzeit , Donald E. Ingber BioEssays. 2025;47(7):e70014. doi: 10.1002/bies.70014 Advancements in women's reproductive health have been hindered by insufficient knowledge and the …
FDA/CDER/OND Experience With New Approach Methodologies (NAMs)
ReferenceJia Yao , Jackye Peretz , Ilona Bebenek , Amy Avila , Tessie Alapatt , Bo Lee , Dakshesh Patel , Paul Brown , Karen Davis-Bruno International Journal of Toxicology. 2025:10915818251384270. doi: 10.1177/10915818251384270 The U.S. Food and Drug …
Exploring the potential of computer simulation models in drug testing and biomedical research: a systematic review
ReferenceRahul Mittal , Alan Ho , Harini Adivikolanu , Muskaan Sawhney , Joana R. N. Lemos , Mannat Mittal , Khemraj Hirani Frontiers in Pharmacology. 2025;16. doi: 10.3389/fphar.2025.1644907 IntroductionThe growing limitations of animal models in drug testing and …
Bicontinuous Microarchitected Scaffolds Provide Topographic Cues That Govern Neuronal Behavior and Maturation
ReferencePrince D. Okoro , Kevin Dalsania , Shiril B. Iragavarapu , Benjamin Dela Cruz , Aihik Banerjee , Merve Basaranbilek , Martin F. Haase , Bahman Anvari , Iman Noshadi Advanced Functional Materials. ;n/a(n/a):e09452. doi: 10.1002/adfm.202509452 3D …
Bioprinting of Perfusable Vascularized Organ Models for Drug Development via Sacrificial-Free Direct Ink Writing
ReferenceDongwei Wu , Shumin Pang , Johanna Berg , Yikun Mei , Ahmed S. M. Ali , Viola Röhrs , Beatrice Tolksdorf , Judith Hagenbuchner , Michael J. Ausserlechner , Hedwig E. Deubzer , Aleksander Gurlo , Jens Kurreck Advanced Functional Materials. …
Leveraging innovative research tools to meet public health challenges: a BioMed21 workshop report
ReferenceFrancesca Pistollato , Fabia Furtmann , Sarah Abitbol , Marta Agostinho , Toni Andreu , Bianca Baluta , Regina G. H. Beets-Tan , Sonja Beken , Silvia Ciotti , Sandra Coecke , Tiago Correia , Christian Desaintes , Frédéric Destrebecq , Philippe Detilleux , …