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A microfluidic platform for the co-culturing of microtissues with continuously recirculating suspension cells
ReferenceChristian Lohasz , Tamara Häfeli , Dzhansu Hasanova , Lisa Hölting , Michal Rudnik , Laure-Anne Ligeon , Svenja Lützow , Avni Mehta , Bettina Kritzer , Sandra Laternser , Javad Nazarian , Andreas Hierlemann , Olivier Frey , Mario M. Modena Microsystems & …
Microglia-containing neural organoids as brain microphysiological systems for long-term culture
ReferenceAlex Rittenhouse , Caroline Krall , Jesse Plotkin , Dowlette-Mary Alam El Din , Breanne Kincaid , Jason Laird , Lena Smirnova Frontiers in Cellular Neuroscience. 2025;19. doi: 10.3389/fncel.2025.1616470 Microglia, essential for brain development, …
Mapping the ethical and sustainable transition in toxicology: a bibliometric analysis and a review of new approach methodologies
ReferenceRuxandra Malina Petrescu-Mag , Mathieu Vinken , Dacinia Crina Petrescu Archives of Toxicology. 2025. doi: 10.1007/s00204-025-04209-7 Toxicology is undergoing a paradigm shift, driven by the ethical imperative to reduce animal testing, the pursuit of …
Nonclinical human neural new approach methodologies (NAMs): Electrophysiological assessment of opioid agonist and antagonist combination
ReferenceCarlos Serna , Bhavya Bhardwaj , Tromondae K. Feaster , Ksenia Blinova NAM Journal. 2025;1:100064. doi: 10.1016/j.namjnl.2025.100064 Background and Purpose New approach methodologies (NAMs) including microphysiological systems in combination with human …
High prevalence of articles with image-related problems in animal studies of subarachnoid hemorrhage and low rates of correction by publishers
ReferenceRené Aquarius , Merel van de Voort , Hieronymus D. Boogaarts , P. Manon Reesink , Kimberley E. Wever PLOS Biology. ;23(10):e3003438. doi: 10.1371/journal.pbio.3003438 Scientific progress relies on science’s capacity for self-correction. If erroneous …
Quantitative systems toxicology: modelling to mechanistically understand and predict drug safety
ReferenceChristopher E. Goldring , Giusy Russomanno , Carmen Pin , Panuwat Trairatphisan , Kylie A. Beattie , Ciarán P. Fisher , Janet Piñero , Richard J. Brennan , Diana Clausznitzer , Ian M. Copple , Theo M. de Kok , Carrie A. Duckworth , Laura I. Furlong , …
Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling
ReferenceColin O’Hern , Sammantha Caywood , Shakhlo Aminova , Artem Kiselev , Brett Volmert , Weiheng Cao , Fei Wang , Mia Dionise , Merlinda-Loriane Sewavi , Milana Skoric , Hussain Basrai , Freyda Mannering , Priyadharshni Muniyandi , Mirel Popa , George Boulos …
Modeling antithymocyte globulin-induced microvasculopathy using human iPSC-derived vascularized liver organoids
ReferenceShuntaro Kawamura , Yosuke Yoneyama , Norikazu Saiki , Yunheng Wu , Chiharu Moriya , Rio Ohmura , Mari Maezawa , Yoshihiro Shimada , Yicheng Wang , Kensaku Mori , Noriki Okada , Yasuharu Onishi , Yukihiro Sanada , Yuta Hirata , Yasunaru Sakuma , Takanori …
Lottery before peer review is associated with increased female representation and reduced estimated economic cost in a German funding line
ReferenceFinn Luebber , Sören Krach , Frieder M. Paulus , Lena Rademacher , Rima-Maria Rahal Nature Communications. 2025;16(1):9824. doi: 10.1038/s41467-025-65660-9 Research funding is a key determinant of scientific progress. However, current allocation …
Integrating allostasis and emerging technologies to study complex diseases
ReferenceInWha Park , Hyokyeong Gwon , Yeonjeong Jung , Boyoung Kim , Gaeun Ju , Eugene Sin , Hye In An , Hye Jung Bang , Taegwan Yun , Seung Hwan Lee , Wonsik Lee , Choon-Gon Jang , Hyo-Jong Lee , Chung Sub Kim , Jeongmi Lee , Soah Lee Communications Biology. …