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Human heart-macrophage assembloids mimic immune-cardiac interactions and enable arrhythmia disease modeling

Colin O’Hern, Sammantha Caywood, Shakhlo Aminova, Artem Kiselev, Brett Volmert, Weiheng Cao, Fei Wang, Mia Dionise, Merlinda-Loriane Sewavi, Milana Skoric, Hussain Basrai, Freyda Mannering, Priyadharshni Muniyandi, Mirel Popa, George Boulos, Kyle Wolf, Izabelle Brown, Isabel Nuñez-Regueiro, Amanda Huang, Aleksandra Kostina, Lauren Squire, Curtis Wilkerson, Nagib Chalfoun, Sangbum Park, Nureddin Ashammakhi, Chao Zhou, Christopher Contag, Aitor Aguirre
Cell Stem Cell. 2025;32(11):1671-1690.e13. doi: 10.1016/j.stem.2025.09.011
https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00367-4
Keywords
Assembloid
atrial fibrillation
cardiac development
disease modeling
embryonic monocyte
human heart organoid
inflammasome
pluripotent stem cell
tissue-resident macrophage
Library Collection(s)
Cardiovascular system
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The content of this website is adapted from Krebs et al., Author Guide for Addressing Animal Methods Bias in Publishing. Advanced Science. 2023 Aug 30:e2303226. doi: 10.1002/advs.202303226. © 2023 by Krebs et al. is licensed under CC BY 4.0. Advanced Science, published by Wiley-VCH GmbH. Wiley-VCH GmbH does not endorse the COLAAB, nor our use of the content. 

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