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Revisiting 3Rs: rethinking replacement and new approach methodologies
ReferenceJessica Rosolowski , Tilo Weber , Atena Malakpour-Permlid , Stina Oredsson Frontiers in Toxicology. 2025;7. doi: 10.3389/ftox.2025.1664209 The 3R concept -reduction, refinement, and replacement -a framework for animal research introduced in 1959 by Russel …
Navigating the AI Frontier in Toxicology: Trends, Trust, and Transformation
ReferenceThomas Luechtefeld , Thomas Hartung Current Environmental Health Reports. 2025;12(1):51. doi: 10.1007/s40572-025-00514-6 The integration of artificial intelligence (AI) into toxicology marks a profound paradigm shift in chemical safety science. No longer …
In silico approach for validating organ-on-chips: exemplifying through a skin-on-chip device
ReferenceDeepa Chaturvedi , Joydeb Mukherjee , Ratnesh Jain , Prajakta Dandekar Microfluidics and Nanofluidics. 2025;30(1):6. doi: 10.1007/s10404-025-02863-y The limitations of traditional, animal-model-based preclinical drug testing methodologies have contributed …
Engineered human induced pluripotent stem cell models reveal altered podocytogenesis in congenital heart disease-associated SMAD2 mutations
ReferenceRohan Bhattacharya , Tarsha Ward , Titilola D. Kalejaiye , Alekshyander Mishra , Sophia M. Leeman , Hamidreza Arzaghi , Jonathan G. Seidman , Christine E. Seidman , Samira Musah Nature Biomedical Engineering. 2025:1-20. doi: 10.1038/s41551-025-01543-0 …
The ethical aspects of human organ-on-chip models: A mapping review
ReferenceJesse Weidema , Martine de Vries , Christine Mummery , Nienke de Graeff Stem Cell Reports. 2025;20(11). doi: 10.1016/j.stemcr.2025.102686 https://www.cell.com/stem-cell-reports/abstract/S2213-6711(25)00290-5 Keywords Digital Twins ethics informed consent …
Prioritizing human tissue research: Q&A with Danilo Tagle
ReferenceDanilo Tagle Cell Stem Cell. 2025;32(6):870-872. doi: 10.1016/j.stem.2025.05.009 https://www.cell.com/cell-stem-cell/abstract/S1934-5909(25)00189-4 Library Collection(s) Ethics, policy, and legislation Download Citation BibTeX EndNote X3 XML EndNote 7 XML …
Self-organization of the hematopoietic vascular niche and emergent innate immunity on a chip
ReferenceAndrei Georgescu , Joseph Hai Oved , Jonathan H. Galarraga , Thomas Cantrell , Samira Mehta , Brian M. Dulmovits , Timothy S. Olson , Pouria Fattahi , Anni Wang , Pelin L. Candarlioglu , Asli Muvaffak , Michele M. Kim , Sezin Aday Aydin , Jeongyun Seo , …
Skeletal muscle-on-a-chip in microgravity as a platform for regeneration modeling and drug screening
ReferenceSoochi Kim , Bugra Ayan , Mahdis Shayan , Thomas A. Rando , Ngan F. Huang Stem Cell Reports. 2024;19(8):1061-1073. doi: 10.1016/j.stemcr.2024.06.010 https://www.cell.com/stem-cell-reports/abstract/S2213-6711(24)00190-5 Keywords aging atrophy microgravity …
Construction of multilayered small intestine-like tissue by reproducing interstitial flow
ReferenceSayaka Deguchi , Kaori Kosugi , Naoki Takeishi , Yukio Watanabe , Shiho Morimoto , Ryosuke Negoro , Fuki Yokoi , Hiroki Futatsusako , May Nakajima-Koyama , Mio Iwasaki , Takuya Yamamoto , Yoshiya Kawaguchi , Yu-suke Torisawa , Kazuo Takayama Cell Stem …
A human pluripotent stem cell-based somitogenesis model using microfluidics
ReferenceYue Liu , Yung Su Kim , Xufeng Xue , Yuchuan Miao , Norio Kobayashi , Shiyu Sun , Robin Zhexuan Yan , Qiong Yang , Olivier Pourquié , Jianping Fu Cell Stem Cell. 2024;31(8):1113-1126.e6. doi: 10.1016/j.stem.2024.06.004 …