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Primitive macrophages enable long-term vascularization of human heart-on-a-chip platforms
ReferenceShira Landau , Yimu Zhao , Homaira Hamidzada , Gregory M. Kent , Sargol Okhovatian , Rick Xing Ze Lu , Chuan Liu , Karl T. Wagner , Krisco Cheung , Sarah A. Shawky , Daniel Vosoughi , Erika Leigh Beroncal , Ian Fernandes , Carolyn L. Cummins , Ana C. …
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes
ReferenceDennis M. Nahon , Marc Vila Cuenca , Francijna E. van den Hil , Michel Hu , Tessa de Korte , Jean-Philippe Frimat , Arn M. J. M. van den Maagdenberg , Christine L. Mummery , Valeria V. Orlova Stem Cell Reports. 2024;19(7):946-956. doi: …
Vascularized hiPSC-derived 3D cardiac microtissue on chip
ReferenceUlgu Arslan , Marcella Brescia , Viviana Meraviglia , Dennis M. Nahon , Ruben W. J. van Helden , Jeroen M. Stein , Francijna E. van den Hil , Berend J. van Meer , Marc Vila Cuenca , Christine L. Mummery , Valeria V. Orlova Stem Cell Reports. …
Vascular defects associated with hereditary hemorrhagic telangiectasia revealed in patient-derived isogenic iPSCs in 3D vessels on chip
ReferenceValeria V. Orlova , Dennis M. Nahon , Amy Cochrane , Xu Cao , Christian Freund , Francijna van den Hil , Cornelius J. J. Westermann , Repke J. Snijder , Johannes Kristian Ploos van Amstel , Peter ten Dijke , Franck Lebrin , Hans-Jurgen Mager , Christine …
Perfusable Brain Microvascular Network-On-Chip Model to Study Flavivirus NS1-Induced Endothelial Dysfunction
ReferenceMonika Rajput , Yen-Ting Tung , Yu-Chi Chen , Min Jae Song , Marc Ferrer , Emily M. Lee Advanced Functional Materials. ;n/a(n/a):e04476. doi: 10.1002/adfm.202504476 Flaviviruses can lead to severe neurotropic-encephalitic pathology, for which the viral …
New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?
ReferenceShivangi Shrimali , Minjun Chen , Dongying Li , Weida Tong Drug Discovery Today. 2025;30(9):104452. doi: 10.1016/j.drudis.2025.104452 The FDA’s ‘Roadmap to Reducing Animal Testing in Preclinical Safety Studies’ supports the regulatory advancement of new …
An immune-competent lung-on-a-chip for modelling the human severe influenza infection response
ReferenceRachel Ringquist , Eshant Bhatia , Paramita Chatterjee , Drishti Maniar , Zhou Fang , Page Franz , Liana Kramer , Delta Ghoshal , Neha Sonthi , Emma Downey , Joshua Canlas , Abigail Ochal , Savi Agarwal , Valeria Cuéllar , Grace Harrigan , Ahmet F. Coskun …
High-throughput cytokine detection platform for evaluation of chemical induced microglial activation
ReferenceShu Yang , Kelly E. Carstens , Ibukunoluwa Ipaye , Xing Chen , Helena T. Hogberg , Nicole Kleinstreuer , Thomas B. Knudsen , Menghang Xia SLAS Technology. 2025;35. doi: 10.1016/j.slast.2025.100347 …
Machine learning-enabled detection of electrophysiological signatures in iPSC-derived models of schizophrenia and bipolar disorder
ReferenceKai Cheng , Autumn Williams , Anannya Kshirsagar , Sai Kulkarni , Rakesh Karmacharya , Deok-Ho Kim , Sridevi V. Sarma , Annie Kathuria APL Bioengineering. 2025;9(3):036118. doi: 10.1063/5.0250559 Neuropsychiatric disorders such as schizophrenia (SCZ) and …
Institutional animal care and use committees and the challenges of evaluating animal research proposals
ReferenceJohn J. Pippin , Jarrod Bailey , Mark Kennedy , Deborah Dubow Press , Janine McCarthy , Ron Baron , Stephen Farghali , Elizabeth Baker , Neal D. Barnard Research Integrity and Peer Review. 2025;10(1):11. doi: 10.1186/s41073-025-00169-9 BACKGROUND: In the …