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An industry perspective on the FDA Modernization Act 2.0/3.0: potential next steps for sponsors to reduce animal use in drug development
ReferenceSarah A Carratt , Christina L Zuch de Zafra , Elias Oziolor , Payal Rana , Nichole R Vansell , Raja Mangipudy , Vishal S Vaidya Toxicological Sciences. 2025;203(1):28-34. doi: 10.1093/toxsci/kfae122 Pharmaceutical developers are encouraged to adopt the …
Accelerating adoption of new approach methodologies in regulatory decision making: an industry perspective
ReferenceAndrew S. Robertson , Nahid Latif , Imein Bousnina , Donna Boyce , Kevin Carl , Sean P. Curtis , Jennifer Dudinak , Carlos O. Garner , Michael Garvin , Sabine Luik , Koen Nauwelaerts , Eddie Reilly , Michelle Rohrer , Katrin Rupalla , Jacintha Shenton , …
A novel rapalog shows improved safety vs. efficacy in a human organoid model of polycystic kidney disease
ReferenceRamila E. Gulieva , Parvaneh Ahmadvand , Benjamin S. Freedman Stem Cell Reports. 2025;20(2). doi: 10.1016/j.stemcr.2024.102395 https://www.cell.com/stem-cell-reports/abstract/S2213-6711(24)00355-2 Keywords AKT IC50 S6 ciliopathy Drug Discovery immunoblot …
Insights on Three Dimensional Organoid Studies for Stem Cell Therapy in Regenerative Medicine
ReferencePrecious Earldom Mulaudzi , Heidi Abrahamse , Anine Crous Stem Cell Reviews and Reports. 2024;20(2):509-523. doi: 10.1007/s12015-023-10655-6 Regenerative medicine has developed as a promising discipline that utilizes stem cells to address limitations in …
Vincristine Treatment Protects Against Podocyte Damage in Focal Segmental Glomerulosclerosis
ReferenceWilliam J. Mason , Jennifer C. Chandler , Alice M. Gage , Gideon Pomeranz , Karen L. Price , Marilina Antonelou , Scott R. Henderson , Laura Perin , Stefano Da Sacco , Alan D. Salama , David A. Long , Ruth J. Pepper Kidney International Reports. 2025. …
Pursuing societal impact in research projects on NAM development: An analysis of routes to impact
ReferenceTessel B. Wijne , Wouter P. C. Boon , Anne S. Kienhuis , Ellen H. M. Moors , Jarno Hoekman NAM Journal. 2025;1:100050. doi: 10.1016/j.namjnl.2025.100050 New Approach Methodologies (NAMs) for risk assessment of chemicals and pharmaceuticals are widely …
Addressing neuroinflammation in human induced pluripotent stem cell-derived central nervous system neurospheroids
ReferenceCatarina M. Gomes , Daniel Simão , Carolina Cardoso Gonçalves , Gabriela Silva , Beatriz Painho , Paula Marques Alves , Catarina Brito iScience. 2025;28(9). doi: 10.1016/j.isci.2025.113246 SummaryGrowing evidence suggests that reactive …
New Approach Methodologies for evaluating Developmental And Reproductive Toxicity potential: review on state of the art, applicability for cosmetic related ingredients and coverage of developmental stages
ReferenceM. Burbank , N. J. Hewitt , F. Gautier , A. Noel-Voisin , N. Golbamaki , R. Grall , M. Leonard , L. Carron , A. Riu , S. Emery , A. Detroyer , T. Bringel , L. Guillet-Revol , N. de Croze , G. Ouédraogo NAM Journal. 2025:100055. doi: …
Integration of lymphatic vasculature to a human lymph node-on-chip enhances physiological immune properties
ReferenceAndrew I. Morrison , Jonas Jäger , Charlotte M. de Winde , Tanja Konijn , Henk P. Roest , Luc J. W. van der Laan , Susan Gibbs , Jasper J. Koning , Reina E. Mebius Materials Today Bio. 2025;35:102326. doi: 10.1016/j.mtbio.2025.102326 To study systemic …
Promoting ethical and reproducible cell culture: implementing animal-free alternatives to teaching in molecular and cell biology
ReferenceAlexandra Nessar , Viola Röhrs , Mathias Ziersch , Ahmed S. M. Ali , Julia Moradi , Anke Kurreck , Johanna Berg , Jens Kurreck Frontiers in Toxicology. 2025;7. doi: 10.3389/ftox.2025.1670513 The widespread use of fetal bovine serum (FBS) and other …