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“Lost in translation?” Animal research in the era of precision medicine
ReferenceHamideh Frühwein , Norbert W. Paul Journal of Translational Medicine. 2025;23(1):152. doi: 10.1186/s12967-025-06084-3 Preclinical animal research has long been a cornerstone in evaluating the efficacy, toxicity, and safety of potential drug treatments …
Open peer review correlates with altmetrics but not with citations: Evidence from <i>Nature Communications</i> and <i>PLoS One</i>
ReferenceXi Cheng , Haoran Wang , Li Tang , Weiyan Jiang , Maotian Zhou , Guoyan Wang Journal of Informetrics. 2024;18(3):101540. doi: 10.1016/j.joi.2024.101540 Against the backdrop of increasing transparency in scientific publications and the complexity of …
Individualized patient tumor organoids faithfully preserve human brain tumor ecosystems and predict patient response to therapy
ReferenceTianping Peng , Xiujian Ma , Wei Hua , Changwen Wang , Youjun Chu , Meng Sun , Valentina Fermi , Stefan Hamelmann , Katharina Lindner , Chunxuan Shao , Julia Zaman , Weili Tian , Yue Zhuo , Yassin Harim , Nadja Stöffler , Linda Hammann , Qungen Xiao , …
Modeling memory B cell responses in a lymphoid organ-chip to evaluate mRNA vaccine boosting
ReferenceRaphaël Jeger-Madiot , Delphine Planas , Isabelle Staropoli , Hippolyte Debarnot , Jérôme Kervevan , Héloïse Mary , Camilla Collina , Barbara F. Fonseca , Rémy Robinot , Stacy Gellenoncourt , Olivier Schwartz , Lorna Ewart , Michael Bscheider , Samy Gobaa …
Registered reports: A method to increase the credibility of published results
ReferenceBrian A. Nosek , Daniël Lakens Social Psychology. 2014;45(3):137-141. doi: 10.1027/1864-9335/a000192 The published journal article is the primary means of communicating scientific ideas, methods, and empirical data. Not all ideas and data get published. …
Modelling metastasis in a dish: in vitro approaches for studying breast cancer progression
ReferenceIrem Duman , Verena Pichler Pathology and Oncology Research. 2025;31:1612179. doi: 10.3389/pore.2025.1612179 Cancer metastasis, driven by cell migration, remains the leading cause of cancer-related deaths. In breast cancer, its high metastatic potential …
Cancer Metastasis-on-a-Chip for Modeling Metastatic Cascade and Drug Screening
ReferenceAnastasia Brooks , Yali Zhang , Jiezhong Chen , Chun-Xia Zhao Advanced Healthcare Materials. 2024;13(21):2302436. doi: 10.1002/adhm.202302436 Microfluidic chips are valuable tools for studying intricate cellular and cell–microenvironment interactions. …
A fully iPS-cell-derived 3D model of the human blood–brain barrier for exploring neurovascular disease mechanisms and therapeutic interventions
ReferenceJudit González-Gallego , Katalin Todorov-Völgyi , Stephan A. Müller , Sophie Antesberger , Mihail Ivilinov Todorov , Rainer Malik , Rita Grimalt-Mirada , Carolina Cardoso Gonçalves , Martina Schifferer , Georg Kislinger , Isabel Weisheit , Barbara Lindner …
Meta-analysis of the make-up and properties of in vitro models of the healthy and diseased blood–brain barrier
ReferenceJames G. Shamul , Zhiyuan Wang , Hyeyeon Gong , Wenquan Ou , Alisa M. White , Diogo P. Moniz-Garcia , Shuo Gu , Alisa Morss Clyne , Alfredo Quiñones-Hinojosa , Xiaoming He Nature Biomedical Engineering. 2025;9(4):566-598. doi: 10.1038/s41551-024-01250-2 …
Next Generation Experimental Models of Venous Physiology and Pathology: Examining Human Relevance in Recapitulating Lower Extremity Flow and Valve Function in New Approach Methods (NAMs)
ReferenceSreelakshmy Suresh , Rana Dhar , Colin E. Evans , Mark Hoofnagle , Abhishek Jain Small. ;n/a(n/a):e10352. doi: 10.1002/smll.202510352 Venous return depends on compliant vessels, competent valves, and auxiliary pumps such as the calf and thoracic muscles. …