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Taking the 3Rs to a higher level: replacement and reduction of animal testing in life sciences in space research
ReferenceMathieu Vinken , Daniela Grimm , Sarah Baatout , Bjorn Baselet , Afshin Beheshti , Markus Braun , Anna Catharina Carstens , James A. Casaletto , Ben Cools , Sylvain V. Costes , Phoebe De Meulemeester , Bartu Doruk , Sara Eyal , Miguel J. S. Ferreira , …
Expression of the transcription factor PU.1 induces the generation of microglia-like cells in human cortical organoids
ReferenceBilal Cakir , Yoshiaki Tanaka , Ferdi Ridvan Kiral , Yangfei Xiang , Onur Dagliyan , Juan Wang , Maria Lee , Allison M. Greaney , Woo Sub Yang , Catherine duBoulay , Mehmet Hamdi Kural , Benjamin Patterson , Mei Zhong , Jonghun Kim , Yalai Bai , Wang Min …
Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines,
ReferenceDonald E. Ingber Cell Stem Cell. 2026. doi: 10.1016/j.stem.2025.12.022 The Food and Drug Administration recently announced a plan to phase out animal-testing requirements for drug assessments based on advances in new approach methodologies, including …
Rethinking Matrigel: The Complex Journey to Matrix Alternatives in Organoid Culture
ReferenceLisa Wolff , Sven Hendrix Advanced Science. 2025;12(47):e08734. doi: 10.1002/advs.202508734 Matrigel is a crucial tool in cell biology, particularly for organoid research. It forms a stable scaffold with components like basement membrane proteins and …
Reasons to Reduce Surplus Animals in Research (in Switzerland) – Or Why the Killing and Death of Animals and Potentially Standard Husbandry Conditions Should be Classified as Harms
ReferenceMatthias Eggel , Samuel Camenzind , Paulin Jirkof LEOH - Journal of Animal Law, Ethics and One Health. 2026:1-15. doi: 10.58590/leoh.2026.001 In Switzerland, approximately 1.2 million animals are used annually for scientific purposes. This number includes …
Distinct SOX9 single-molecule dynamics characterize adult differentiation and fetal-like reprogrammed states in intestinal organoids
ReferenceNike Walther , Sathvik Anantakrishnan , Gina M. Dailey , Anna C. Maurer , Claudia Cattoglio Stem Cell Reports. 2026. doi: 10.1016/j.stemcr.2025.102787 SummaryTranscription factors (TFs) mediate gene expression changes during differentiation …
Generation and characterization of iPSC models from HIV-1-positive individuals with divergent clinical outcomes
ReferenceNathalia Almeida , Sam Acors , Daniel Cox , Neophytos Kouphou , Lazaros Fotopoulos , Thomas Williams , Patricia A. Otto , Eun-Young Kim , Steven M. Wolinsky , Davide Danovi , Alessandra Vigilante , Michael H. Malim , Luis Apolonia Stem Cell Reports. 2026. …
Peer review across borders: benefits and challenges of international review panels in research funding organizations
ReferenceHelen Peterson , Liisa Husu Research Evaluation. 2025;34:rvaf030. doi: 10.1093/reseval/rvaf030 Peer review by external experts is widely recognized as a legitimate and trustworthy academic practice, essential for ensuring the quality and rigor of …
Gender gaps in the peer review process. Different sources in the evaluation process for the allocation of grants in Argentina
ReferenceFlorencia Fiorentin , Diana Suarez Research Evaluation. 2025;34:rvaf048. doi: 10.1093/reseval/rvaf048 This paper examines gender gaps in three dimensions of peer review for research grant allocation: relevance, feasibility, and academic background of …
Defining the role of cognitive distance in the peer review process with an explorative study of a grant scheme in infection biology
ReferenceQi Wang , Ulf Sandström Research Evaluation. 2015;24(3):271-281. doi: 10.1093/reseval/rvv009 The aim of this article is twofold: (1) to provide a methodology for measurement of cognitive distance between researchers and (2) to explore the role of …