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The benefits of preregistration and Registered Reports
ReferenceDaniël Lakens , Cristian Mesquida , Sajedeh Rasti , Massimiliano Ditroilo Evidence-Based Toxicology. 2024;2(1):2376046. doi: 10.1080/2833373X.2024.2376046 Practices that introduce systematic bias are common in most scientific disciplines, including …
A glia-enriched stem cell 3D model of the human brain mimics the glial-immune neurodegenerative phenotypes of multiple sclerosis
ReferenceFrancesca Fagiani , Edoardo Pedrini , Stefano Taverna , Elena Brambilla , Valentina Murtaj , Paola Podini , Francesca Ruffini , Erica Butti , Clarissa Braccia , Annapaola Andolfo , Roberta Magliozzi , Lena Smirnova , Tanja Kuhlmann , Angelo Quattrini , …
Use of animals for scientific and educational purposes by Mexican institutions
ReferencePatricia Frías-Álvarez , Gustavo Ortiz-Millán Gaceta Médica de México. 2024;160(2):212-220. In Mexico, it is not known which institutions use animals for scientific purposes. This work reports, based on data requested from the National Institute of ... …
Rethinking the Three Rs: Growing Momentum Toward a New Gold Standard in Australian Research
ReferenceNatalie Anderson , Rachel Smith Alternatives to Laboratory Animals. 2024;52(4):224-231. doi: 10.1177/02611929241259117 Recent years have seen increasing recognition of the scientific, economic and ethical benefits of the use of non-animal models in …
Bridging the Gap: Integrating 3D Bioprinting and Microfluidics for Advanced Multi-Organ Models in Biomedical Research
ReferenceMarco De Spirito , Valentina Palmieri , Giordano Perini , Massimiliano Papi Bioengineering. 2024;11(7):664. doi: 10.3390/bioengineering11070664 Recent advancements in 3D bioprinting and microfluidic lab-on-chip systems offer promising solutions to the …
Application of microphysiological systems for nonclinical evaluation of cell therapies
ReferencePelin L. Candarlioglu , Louise Delsing , Lauren Gauthier , Lauren Lewis , George Papadopoulos , May Freag , Tom S. Chan , Kimberly A. Homan , Mick D. Fellows , Amy Pointon , Kyle Kojala Alternatives to Animal Experimentation. 2024;41(3):469-484. doi: …
Impact of brain organoid-derived sEVs on metastatic adaptation and invasion of breast carcinoma cells through a microphysiological system
ReferenceHojjatollah Nazari , Ann-Na Cho , Dale Goss , Jean Paul Thiery , Majid Ebrahimi Warkiani Lab on a Chip. 2024;24(14):3434-3455. doi: 10.1039/D4LC00296B Brain metastases are common in triple-negative breast cancer (TNBC), suggesting a complex process of …
Microfluidic gut-axis-on-a-chip models for pharmacokinetic-based disease models
ReferenceRaehyun Kim , Jong Hwan Sung Biomicrofluidics. 2024;18:031507. doi: 10.1063/5.0206271 The low success rate of new drugs transitioning from animal testing to human clinical trials necessitates the development of more accurate and representative in vitro …
Collaborative ethics: innovating collaboration between ethicists and life scientists
ReferenceJeantine E. Lunshof , Julia Rijssenbeek Nature Methods. 2024:1-4. doi: 10.1038/s41592-024-02320-8 Scientific breakthroughs can change how we understand and live in the world, disrupting long-held assumptions and concepts and raising new questions for …
Lubricant-Coated Organ-on-a-Chip for Enhanced Precision in Preclinical Drug Testing
ReferenceTae Young Kim , Jeong-Won Choi , Kijun Park , SeungHwan Kim , Jeong F. Kim , Tae-Eun Park , Jungmok Seo Small. 2024:2402431. doi: 10.1002/smll.202402431 In drug discovery, human organ-on-a-chip (organ chip) technology has emerged as an essential tool for …