Search
Chamber-specific contractile responses of atrial and ventricular hiPSC-cardiomyocytes to GPCR and ion channel targeting compounds: A microphysiological system for cardiac drug development
ReferenceBettina Lickiss , Jan Hunker , Jamie Bhagwan , Peter Linder , Ulrich Thomas , Hardeep Lotay , Steven Broadbent , Elena Dragicevic , Sonja Stoelzle-Feix , Jan Turner , Matthias Gossmann Journal of Pharmacological and Toxicological Methods. 2024;128:107529. …
Microfluidic human physiomimetic liver model as a screening platform for drug induced liver injury
ReferenceSouradeep Dey , Amritha Bhat , G. Janani , Vartik Shandilya , Raghvendra Gupta , Biman B. Mandal Biomaterials. 2024;310:122627. doi: 10.1016/j.biomaterials.2024.122627 The pre-clinical animal models often fail to predict intrinsic and idiosyncratic drug …
A personalized osteoarthritic joint-on-a-chip as a screening platform for biological treatments
ReferenceDalila Petta , Daniele D'Arrigo , Shima Salehi , Giuseppe Talò , Lorenzo Bonetti , Marco Vanoni , Luca Deabate , Luigi De Nardo , Gabriele Dubini , Christian Candrian , Matteo Moretti , Silvia Lopa , Chiara Arrigoni Materials Today Bio. 2024;26:101072. …
Technological advances and challenges in constructing complex gut organoid systems
ReferenceLongjin Zheng , Yang Zhan , Chenxuan Wang , Qigui Fan , Denglong Sun , Yingmeng Li , Yanxia Xiong Frontiers in Cell and Developmental Biology. 2024;12. doi: 10.3389/fcell.2024.1432744 Recent advancements in organoid technology have heralded a …
Human organs-on-chips for disease modelling, drug development and personalized medicine
ReferenceDonald E Ingber Nature Reviews Genetics. 25;23(8):467-491. doi: 10.1038/s41576-022-00466-9 https://doi.org/10.1038/s41576-022-00466-9 Library Collection(s) Reviews and perspectives Download Citation BibTeX EndNote X3 XML EndNote 7 XML EndNote tagged Marc …
Mission Creep or Mission Lapse? Scientific Review in Research Oversight
ReferenceMargaret Waltz , Jill A. Fisher , Rebecca L. Walker AJOB Empirical Bioethics. 2023;14(1):38-49. doi: 10.1080/23294515.2022.2123868 https://doi.org/10.1080/23294515.2022.2123868 Keywords IACUCs IRBs Scientific review animal research human subjects research …
PRIVAT Tool
ReferencePaul Whaley , Carlijn R. Hooijmans 2022. Deriving a tool to support peer-review of in vitro study manuscripts, from a quality criteria item bank and using a Delphi process Hosted on the Open Science Framework https://osf.io/bwypt/ Library Collection(s) …
Institution animal care and use committees need greater ethical diversity
ReferenceLawrence Arthur Hansen Journal of Medical Ethics. 2013;39(3):188-190. doi: 10.1136/medethics-2012-100982 In response to public outrage stemming from exposés of animal abuse in research laboratories, the US Congress in 1985 mandated Institutional Animal …
The Sydney Heart Bank: improving translational research while eliminating or reducing the use of animal models of human heart disease
ReferenceC. G. dos Remedios , S. P. Lal , A. Li , J. McNamara , A. Keogh , P. S. Macdonald , R. Cooke , E. Ehler , R. Knöll , S. B. Marston , J. Stelzer , H. Granzier , C. Bezzina , S. van Dijk , F. De Man , G. J. M. Stienen , J. Odeberg , F. Pontén , W. Linke , …
Technological lock-in, positive institutional feedback, and research on laboratory animals
ReferenceJoshua Frank Structural Change and Economic Dynamics. 2005;16(4):557-575. doi: 10.1016/j.strueco.2004.11.001 There has been considerable debate over the efficacy of animal research. The focus here is on bridging the gap between the current animal research …