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In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids
ReferenceDaniel Reumann , Christian Krauditsch , Maria Novatchkova , Edoardo Sozzi , Sakurako Nagumo Wong , Michael Zabolocki , Marthe Priouret , Balint Doleschall , Kaja I. Ritzau-Reid , Marielle Piber , Ilaria Morassut , Charles Fieseler , Alessandro Fiorenzano …
Human cerebellar organoids with functional Purkinje cells
ReferenceAlexander Atamian , Marcella Birtele , Negar Hosseini , Tuan Nguyen , Anoothi Seth , Ashley Del Dosso , Sandeep Paul , Neil Tedeschi , Ryan Taylor , Marcelo P. Coba , Ranmal Samarasinghe , Carlos Lois , Giorgia Quadrato Cell Stem Cell. …
Biochemical and transcriptomic evaluation of a 3D lung organoid platform for pre-clinical testing of active substances targeting senescence
ReferenceMichelle Brand , Felix Ritzmann , Kathrin Kattler , Deivydas Milasius , Yiwen Yao , Christian Herr , Susanne H. Kirsch , Rolf Müller , Daniela Yildiz , Robert Bals , Christoph Beisswenger Respiratory Research. 2024;25:3. doi: 10.1186/s12931-023-02636-7 …
Engineering Organ-on-a-Chip Systems for Vascular Diseases
ReferenceAmid Shakeri , Ying Wang , Yimu Zhao , Shira Landau , Kevin Perera , Jonguk Lee , Milica Radisic Arteriosclerosis, Thrombosis, and Vascular Biology. 2023;43(12):2241-2255. doi: 10.1161/ATVBAHA.123.318233 Vascular diseases, such as atherosclerosis and …
Analysis of off-tumour toxicities of T-cell-engaging bispecific antibodies via donor-matched intestinal organoids and tumouroids
ReferenceMarius F. Harter , Timothy Recaldin , Regine Gerard , Blandine Avignon , Yannik Bollen , Cinzia Esposito , Karolina Guja-Jarosz , Kristina Kromer , Adrian Filip , Julien Aubert , Anneliese Schneider , Marina Bacac , Michael Bscheider , Nadine …
Using Human-Induced Pluripotent Stem Cell Derived Neurons on Microelectrode Arrays to Model Neurological Disease: A Review
ReferenceLV Shiya , Enhui He , Jinping Luo , Yaoyao Liu , Wei Liang , Shihong Xu , Kui Zhang , Yan Yang , Mixia Wang , Yilin Song , Yirong Wu , Xinxia Cai Advanced Science. 2023;10(33):2301828. doi: 10.1002/advs.202301828 In situ physiological signals of in vitro …
Immunocompetent PDMS-Free Organ-on-Chip Model of Cervical Cancer Integrating Patient-Specific Cervical Fibroblasts and Neutrophils
ReferenceElena Kromidas , Alicia Geier , Adrian Weghofer , Hui-Yu Liu , Martin Weiss , Peter Loskill Advanced Healthcare Materials. 2023:2302714. doi: 10.1002/adhm.202302714 Despite preventive measures and available treatments, cervical cancer still ranks as the …
Listen to Your Gut: Key Concepts for Bioengineering Advanced Models of the Intestine
ReferenceOliver Cameron , Joana F. Neves , Eileen Gentleman Advanced Science. 2024;11(5):2302165. doi: 10.1002/advs.202302165 The intestine performs functions central to human health by breaking down food and absorbing nutrients while maintaining a selective …
Cancer-on-chip models for metastasis: importance of the tumor microenvironment
ReferenceMohammad Jouybar , Charlotte M. de Winde , Katarina Wolf , Peter Friedl , Reina E. Mebius , Jaap M. J. den Toonder Trends in Biotechnology. 2024;42(4):431-448. doi: 10.1016/j.tibtech.2023.10.001 …
BBB-on-a-chip with integrated micro-TEER for permeability evaluation of multi-functionalized gold nanorods against Alzheimer’s disease
ReferenceSujey Palma-Florez , Adrián López-Canosa , Francisco Moralez-Zavala , Oscar Castaño , Marcelo J. Kogan , Josep Samitier , Anna Lagunas , Mònica Mir Journal of Nanobiotechnology. 2023;21:115. doi: 10.1186/s12951-023-01798-2 The lack of predictive models …