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The human subject: an integrative animal model for 21st century heart failure research
ReferenceP Charukeshi Chandrasekera , John J Pippin American Journal of Translational Research. 2015;7(9):1636-1647. Heart failure remains a leading cause of death and it is a major cause of morbidity and mortality affecting tens of millions of people worldwide. …
Multi-lineage heart-chip models drug cardiotoxicity and enhances maturation of human stem cell-derived cardiovascular cells
ReferenceMaedeh Mozneb , Amelia Jenkins , Samuel Sances , Stephany Pohlman , Michael J. Workman , Dylan West , Briana Ondatje , Kareem El-Ghazawi , Amanda Woodbury , Veronica J. Garcia , Shachi Patel , Madelyn Arzt , Felipe Dezem , Alex H. Laperle , V. Alexandra …
The case of the missing mouse—developing cystic fibrosis drugs without using animals
ReferenceLindsay J. Marshall , Kathleen M. Conlee Frontiers in Drug Discovery. 2024;4. doi: 10.3389/fddsv.2024.1347246 Creating and developing new drugs can take decades, costs millions of dollars, requires untold human effort and usually, takes thousands of …
The Promise and Potential of Brain Organoids
ReferenceLena Smirnova , Thomas Hartung Advanced Healthcare Materials. 2024:2302745. doi: 10.1002/adhm.202302745 Brain organoids are 3D in vitro culture systems derived from human pluripotent stem cells that self-organize to model features of the (developing) …
An iPSC-derived small intestine-on-chip with self-organizing epithelial, mesenchymal, and neural cells
ReferenceRenée Moerkens , Joram Mooiweer , Aarón D. RamÃrez-Sánchez , Roy Oelen , Lude Franke , Cisca Wijmenga , Robert J. Barrett , Iris H. Jonkers , Sebo Withoff Cell Reports. 2024;43(7). doi: 10.1016/j.celrep.2024.114247 …
Impaired neuron differentiation in GBA-associated Parkinson’s disease is linked to cell cycle defects in organoids
ReferenceIsabel Rosety , Alise Zagare , Claudia Saraiva , Sarah Nickels , Paul Antony , Catarina Almeida , Enrico Glaab , Rashi Halder , Sergiy Velychko , Thomas Rauen , Hans R. Schöler , Silvia Bolognin , Thomas Sauter , Javier Jarazo , Rejko Krüger , Jens C. …
Towards in vitro models for reducing or replacing the use of animals in drug testing
ReferenceDavid M. Stresser , Anna K. Kopec , Philip Hewitt , Rhiannon N. Hardwick , Terry R. Van Vleet , Prathap Kumar S. Mahalingaiah , Denice O’Connell , Gary J. Jenkins , Rhiannon David , Jessica Graham , Donna Lee , Jason Ekert , Aaron Fullerton , Remi …
Taking the leap toward human-specific nonanimal methodologies: The need for harmonizing global policies for microphysiological systems
ReferenceSurat Parvatam , David Pamies , Francesca Pistollato , Sonja Beken , Indumathi Mariappan , Adrian Roth , Monica Piergiovanni , Benoît G. C. Maisonneuve , Lorna Ewart , Abhijit Majumder , Prajakta Dandekar , Rahul Date , Kasturi Mahadik , Saravanan …
Using mice from different breeding sites fails to improve replicability of results from single-laboratory studies
ReferenceIvana Jaric , Bernhard Voelkl , Irmgard Amrein , David P. Wolfer , Janja Novak , Carlotta Detotto , Ulrike Weber-Stadlbauer , Urs Meyer , Francesca Manuella , Isabelle M. Mansuy , Hanno Würbel Lab Animal. 2024;53:18-22. doi: 10.1038/s41684-023-01307-w …
Retinoic acid signaling regulates spatiotemporal specification of human green and red cones
ReferenceSarah E. Hadyniak , Joanna F. D. Hagen , Kiara C. Eldred , Boris Brenerman , Katarzyna A. Hussey , Rajiv C. McCoy , Michael E. G. Sauria , James A. Kuchenbecker , Thomas Reh , Ian Glass , Maureen Neitz , Jay Neitz , James Taylor , Robert J. Johnston Jr …