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Professional quality of life in animal research personnel is linked to retention & job satisfaction: A mixed-methods cross-sectional survey on compassion fatigue in the USA
ReferenceLauren Young , Fabienne Ferrara , Lisa Kelly , Tara Martin , Sally Thompson-Iritani , Megan R. LaFollette PLOS ONE. ;19(4):e0298744. doi: 10.1371/journal.pone.0298744 Background Working with research animals can be both rewarding and challenging. The …
1,026 experimental treatments in acute stroke
ReferenceVictoria E. O'Collins , Malcolm R. Macleod , Geoffrey A. Donnan , Laura L. Horky , Bart H. van der Worp , David W. Howells Annals of Neurology. 2006;59(3):467-477. doi: 10.1002/ana.20741 OBJECTIVE: Preclinical evaluation of neuroprotectants fostered high …
Non-animal models for blood–brain barrier permeability evaluation of drug-like compounds
ReferenceFrederic O. Dehnbostel , Vaibhav A. Dixit , Robert Preissner , Priyanka Banerjee Scientific Reports. 2024;14(1):8908. doi: 10.1038/s41598-024-59734-9 Diseases related to the central nervous system (CNS) are major health concerns and have serious social …
Implementing ‘translational’ biomedical research: Convergence and divergence among clinical and basic scientists
ReferenceMyfanwy Morgan , Christine A. Barry , Jenny L. Donovan , Jane Sandall , Charles D. A. Wolfe , Annette Boaz Social Science & Medicine. 2011;73(7):945-952. doi: 10.1016/j.socscimed.2011.06.060 Universities are increasingly regarded as key actors in the new …
Surveys of current status in biomedical science grant review: funding organisations' and grant reviewers' perspectives
ReferenceSara Schroter , Trish Groves , Liselotte Højgaard BMC Medicine. 2010;8:62. doi: 10.1186/1741-7015-8-62 The objectives of this research were (a) to describe the current status of grant review for biomedical projects and programmes from the perspectives of …
An immune-competent human gut microphysiological system enables inflammation-modulation by Faecalibacterium prausnitzii
ReferenceJianbo Zhang , Yu-Ja Huang , Martin Trapecar , Charles Wright , Kirsten Schneider , John Kemmitt , Victor Hernandez-Gordillo , Jun Young Yoon , Mathilde Poyet , Eric J. Alm , David T. Breault , David L. Trumper , Linda G. Griffith npj Biofilms and …
Replacing Animal Testing with Stem Cell-Organoids : Advantages and Limitations
ReferenceGuiyoung Park , Yeri Alice Rim , Yeowon Sohn , Yoojun Nam , Ji Hyeon Ju Stem Cell Reviews and Reports. 2024. doi: 10.1007/s12015-024-10723-5 Various groups including animal protection organizations, medical organizations, research centers, and even …
NIH peer review percentile scores are poorly predictive of grant productivity
ReferenceFerric C Fang , Anthony Bowen , Arturo Casadevall eLife. 2016;5:e13323. doi: 10.7554/eLife.13323 Peer review is widely used to assess grant applications so that the highest ranked applications can be funded. A number of studies have questioned the ability …
Why Animal Studies are Still Being Used in Drug Development
ReferenceMarlous Kooijman Alternatives to Laboratory Animals. 2013;41(6):79-81. doi: 10.1177/026119291304100627 The lack of success of the implementation of new methods in drug development can be studied from an innovation perspective …
Managing the Rivalry of Competing Institutional Logics
ReferenceTrish Reay , C.R. Hinings Organization Studies. 2009;30(6):629-652. doi: 10.1177/0170840609104803 We investigated an organizational field where competing institutional logics existed for a lengthy period of time. We identified four mechanisms for managing …