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Competing Technologies, Increasing Returns, and Lock-In by Historical Events
ReferenceW. Brian Arthur The Economic Journal. 1989;99(394):116-131. doi: 10.2307/2234208 https://doi.org/10.2307/2234208 Library Collection(s) Bias, peer review, and publishing Download Citation BibTeX EndNote X3 XML EndNote 7 XML EndNote tagged Marc …
Why Most Acute Stroke Studies Are Positive in Animals but Not in Patients: A Systematic Comparison of Preclinical, Early Phase, and Phase 3 Clinical Trials of Neuroprotective Agents
ReferenceAntje Schmidt-Pogoda , Nadine Bonberg , Mailin Hannah Marie Koecke , Jan-Kolja Strecker , Jürgen Wellmann , Nils-Martin Bruckmann , Carolin Beuker , Wolf-Rüdiger Schäbitz , Sven G. Meuth , Heinz Wiendl , Heike Minnerup , Jens Minnerup Annals of Neurology. …
Ethics and Controversies in Animal Subjects Research and Impact on Clinical Decision-Making
ReferenceMichael Balls , Jarrod Bailey Anesthesiology Clinics. 2024. doi: 10.1016/j.anclin.2024.03.003 https://www.sciencedirect.com/science/article/pii/S1932227524000284 Keywords alternative methods animal experimentation Ethical acceptability Scientific …
DEIA is essential to advance the goals of translational science: Perspectives from NCATS
ReferenceShadab F. Hussain , Amanda L. Vogel , Jessica M. Faupel-Badger , Linda Ho , Lameese D. Akacem , Krishna Balakrishnan , Rebekah Geiger , Rashmi Gopal-Srivastava , Brittany Haynes , Marcus G. Hodges , Tanetta Isler , Ewy A. Mathé , Leonie Misquitta , Karlie …
Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived organoids
ReferenceLan Dao , Zhen You , Lu Lu , Tianyang Xu , Avijite Kumer Sarkar , Hui Zhu , Miao Liu , Riccardo Calandrelli , George Yoshida , Pei Lin , Yifei Miao , Sarah Mierke , Srijan Kalva , Haining Zhu , Mingxia Gu , Sudhakar Vadivelu , Sheng Zhong , L. Frank Huang …
Organ-on-a-chip for studying immune cell adhesion to liver sinusoidal endothelial cells: the potential for testing immunotherapies and cell therapy trafficking
ReferenceJames I. Kennedy , Scott P. Davies , Peter W. Hewett , Alex L. Wilkinson , Ye H. Oo , Wei-Yu Lu , Alicia J. El Haj , Shishir Shetty Frontiers in Cell and Developmental Biology. 2024;12. doi: 10.3389/fcell.2024.1359451 Immunotherapy has changed the …
Transition to innovative, human-relevant pre-clinical cardiovascular research: a perspective
ReferenceEvangelos P Daskalopoulos , Pierre Deceuninck , Maurice Whelan , Laura Gribaldo Cardiovascular Research. 2024:cvae080. doi: 10.1093/cvr/cvae080 Cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. It is estimated …
Recommendations for robust and reproducible preclinical research in personalised medicine
ReferenceVibeke Fosse , Emanuela Oldoni , Florence Bietrix , Alfredo Budillon , Evangelos P. Daskalopoulos , Maddalena Fratelli , Björn Gerlach , Peter M. A. Groenen , Sabine M. Hölter , Julia M. L. Menon , Ali Mobasheri , Nikki Osborne , Merel Ritskes-Hoitinga , …
Advances in the Model Structure of In Vitro Vascularized Organ-on-a-Chip
ReferenceHongze Yin , Yue Wang , Na Liu , Songyi Zhong , Long Li , Quan Zhang , Zeyang Liu , Tao Yue Cyborg and Bionic Systems. 2024;5:0107. doi: 10.34133/cbsystems.0107 Microvasculature plays a crucial role in human physiology and is closely related to various …
Recommendations for empowering early career researchers to improve research culture and practice
ReferenceBrianne A. Kent , Constance Holman , Emmanuella Amoako , Alberto Antonietti , James M. Azam , Hanne Ballhausen , Yaw Bediako , Anat M. Belasen , Clarissa F. D. Carneiro , Yen-Chung Chen , Ewoud B. Compeer , Chelsea A. C. Connor , Sophia Crüwell , Humberto …