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Phenome-wide association studies across large population cohorts support drug target validation
ReferenceDorothée Diogo , Chao Tian , Christopher S. Franklin , Mervi Alanne-Kinnunen , Michael March , Chris C. A. Spencer , Ciara Vangjeli , Michael E. Weale , Hannele Mattsson , Elina Kilpeläinen , Patrick M. A. Sleiman , Dermot F. Reilly , Joshua McElwee , …
From target discovery to clinical drug development with human genetics
ReferenceKaterina Trajanoska , Claude Bhérer , Daniel Taliun , Sirui Zhou , J. Brent Richards , Vincent Mooser Nature. 2023;620(7975):737-745. doi: 10.1038/s41586-023-06388-8 The substantial investments in human genetics and genomics made over the past three …
Using genetic association data to guide drug discovery and development: Review of methods and applications
ReferenceStephen Burgess , Amy M. Mason , Andrew J. Grant , Eric A. W. Slob , Apostolos Gkatzionis , Verena Zuber , Ashish Patel , Haodong Tian , Cunhao Liu , William G. Haynes , G. Kees Hovingh , Lotte Bjerre Knudsen , John C. Whittaker , Dipender Gill American …
Using human genetics to improve safety assessment of therapeutics
ReferenceKeren J. Carss , Aimee M. Deaton , Alberto Del Rio-Espinola , Dorothée Diogo , Mark Fielden , Diptee A. Kulkarni , Jonathan Moggs , Peter Newham , Matthew R. Nelson , Frank D. Sistare , Lucas D. Ward , Jing Yuan Nature Reviews. Drug Discovery. …
Advancing the use of genome-wide association studies for drug repurposing
ReferenceWilliam R. Reay , Murray J. Cairns Nature Reviews Genetics. 2021;22(10):658-671. doi: 10.1038/s41576-021-00387-z Genome-wide association studies (GWAS) have revealed important biological insights into complex diseases, which are broadly expected to lead …
Improving the odds of drug development success through human genomics: modelling study
ReferenceAroon D. Hingorani , Valerie Kuan , Chris Finan , Felix A. Kruger , Anna Gaulton , Sandesh Chopade , Reecha Sofat , Raymond J. MacAllister , John P. Overington , Harry Hemingway , Spiros Denaxas , David Prieto , Juan Pablo Casas Scientific Reports. …
Evaluating drug targets through human loss-of-function genetic variation
ReferenceEric Vallabh Minikel , Konrad J. Karczewski , Hilary C. Martin , Beryl B. Cummings , Nicola Whiffin , Daniel Rhodes , Jessica Alföldi , Richard C. Trembath , David A. van Heel , Mark J. Daly , Genome Aggregation Database Production Team , Genome …
Predictive validity in drug discovery: what it is, why it matters and how to improve it
ReferenceJack W. Scannell , James Bosley , John A. Hickman , Gerard R. Dawson , Hubert Truebel , Guilherme S. Ferreira , Duncan Richards , J. Mark Treherne Nature Reviews Drug Discovery. 2022;21(12):915-931. doi: 10.1038/s41573-022-00552-x Successful drug …
Functioning human lung organoids model pulmonary tissue response from carbon nanomaterial exposures
ReferenceRahaf Issa , Neus Lozano , Kostas Kostarelos , Sandra Vranic Nano Today. 2024;56:102254. doi: 10.1016/j.nantod.2024.102254 Human lung organoids (HLOs) are increasingly used to model development and infectious diseases, however their ability to …
Principles and framework for assessing the risk of bias for studies included in comparative quantitative environmental systematic reviews
ReferenceGeoff Frampton , Paul Whaley , Micah Bennett , Gary Bilotta , Jean-Lou C. M. Dorne , Jacqualyn Eales , Katy James , Christian Kohl , Magnus Land , Barbara Livoreil , David Makowski , Evans Muchiri , Gillian Petrokofsky , Nicola Randall , Kate Schofield …