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Positive results receive more citations, but only in some disciplines
ReferenceDaniele Fanelli Scientometrics. 2013;94:701-709. doi: 10.1007/s11192-012-0757-y Negative results are commonly assumed to attract fewer readers and citations, which would explain why journals in most disciplines tend to publish too many positive and …
Systematic Review of the Empirical Evidence of Study Publication Bias and Outcome Reporting Bias — An Updated Review
ReferenceKerry Dwan , Carrol Gamble , Paula R. Williamson , Jamie J. Kirkham PLOS ONE. ;8(7):e66844. doi: 10.1371/journal.pone.0066844 Background The increased use of meta-analysis in systematic reviews of healthcare interventions has highlighted several types of …
Effect of the Statistical Significance of Results on the Time to Completion and Publication of Randomized Efficacy Trials
ReferenceJohn P. A. Ioannidis JAMA. 1998;279(4):281-286. doi: 10.1001/jama.279.4.281 https://doi.org/10.1001/jama.279.4.281 Library Collection(s) Bias, peer review, and publishing Download Citation BibTeX EndNote X3 XML EndNote 7 XML EndNote tagged Marc …
Why Most Published Research Findings Are False
ReferenceJohn P. A. Ioannidis PLOS Medicine. ;2(8):e124. doi: 10.1371/journal.pmed.0020124 Summary There is increasing concern that most current published research findings are false. The probability that a research claim is true may depend on study power and …
Publication Bias in Reports of Animal Stroke Studies Leads to Major Overstatement of Efficacy
ReferenceEmily S. Sena , H. Bart van der Worp , Philip M. W. Bath , David W. Howells , Malcolm R. Macleod PLOS Biology. ;8(3):e1000344. doi: 10.1371/journal.pbio.1000344 Publication bias confounds attempts to use systematic reviews to assess the efficacy of …
Risk of Bias in Reports of In Vivo Research: A Focus for Improvement
ReferenceMalcolm R. Macleod , Aaron Lawson McLean , Aikaterini Kyriakopoulou , Stylianos Serghiou , Arno de Wilde , Nicki Sherratt , Theo Hirst , Rachel Hemblade , Zsanett Bahor , Cristina Nunes-Fonseca , Aparna Potluru , Andrew Thomson , Julija Baginskitae , …
Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke
ReferenceConstance Holman , Sophie K. Piper , Ulrike Grittner , Andreas Antonios Diamantaras , Jonathan Kimmelman , Bob Siegerink , Ulrich Dirnagl PLOS Biology. ;14(1):e1002331. doi: 10.1371/journal.pbio.1002331 Given small sample sizes, loss of animals in …
Refining the impact of genetic evidence on clinical success
ReferenceEric Vallabh Minikel , Jeffery L. Painter , Coco Chengliang Dong , Matthew R. Nelson Nature. 2024:1-6. doi: 10.1038/s41586-024-07316-0 The cost of drug discovery and development is driven primarily by failure1, with only about 10% of clinical programmes …
Prediction of tumor origin in cancers of unknown primary origin with cytology-based deep learning
ReferenceFei Tian , Dong Liu , Na Wei , Qianqian Fu , Lin Sun , Wei Liu , Xiaolong Sui , Kathryn Tian , Genevieve Nemeth , Jingyu Feng , Jingjing Xu , Lin Xiao , Junya Han , Jingjie Fu , Yinhua Shi , Yichen Yang , Jia Liu , Chunhong Hu , Bin Feng , Yan Sun , …
The support of human genetic evidence for approved drug indications
ReferenceMatthew R. Nelson , Hannah Tipney , Jeffery L. Painter , Judong Shen , Paola Nicoletti , Yufeng Shen , Aris Floratos , Pak Chung Sham , Mulin Jun Li , Junwen Wang , Lon R. Cardon , John C. Whittaker , Philippe Sanseau Nature Genetics. 2015;47(8):856-860. …