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3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration
ReferenceHongbing Wang , Paul C. Brown , Edwin C. Y. Chow , Lorna Ewart , Stephen S. Ferguson , Suzanne Fitzpatrick , Benjamin S. Freedman , Grace L. Guo , William Hedrich , Scott Heyward , James Hickman , Nina Isoherranen , Albert P. Li , Qi Liu , Shannon M. …
Opportunities and challenges with microphysiological systems: a pharma end-user perspective
ReferenceLorna Ewart , Adrian Roth Nature Reviews. Drug Discovery. 2021;20(5):327-328. doi: 10.1038/d41573-020-00030-2 Keywords Drug development Drug Discovery Drug Industry Goals Humans Microchip Analytical Procedures Physiology Library Collection(s) Reviews and …
A fully 3D-printed versatile tumor-on-a-chip allows multi-drug screening and correlation with clinical outcomes for personalized medicine
ReferenceEliana Steinberg , Roy Friedman , Yoel Goldstein , Nethanel Friedman , Ofer Beharier , Jonathan Abraham Demma , Gideon Zamir , Ayala Hubert , Ofra Benny Communications Biology. 2023;6(1):1-14. doi: 10.1038/s42003-023-05531-5 Optimal clinical outcomes in …
Getting personal with the “reproducibility crisis”: interviews in the animal research community
ReferenceBen G. Fitzpatrick , Elena Koustova , Yun Wang Lab Animal. 2018;47(7):175-177. doi: 10.1038/s41684-018-0088-6 https://www.nature.com/articles/s41684-018-0088-6 Keywords Biological techniques Drug Discovery medical research Scientific community Scientific …
A randomised controlled trial of an Intervention to Improve Compliance with the ARRIVE guidelines (IICARus)
ReferenceKaitlyn Hair , Malcolm R. Macleod , Emily S. Sena , Emily S. Sena , Kaitlyn Hair , Malcolm R. Macleod , David Howells , Philip Bath , Cadi Irvine , Catriona MacCallum , Gavin Morrison , Alejandra Clark , Gina Alvino , Michelle Dohm , Jing Liao , Chris …
Beyond the 3Rs: Expanding the use of human-relevant replacement methods in biomedical research
ReferenceKathrin Herrmann , Francesca Pistollato , Martin L. Stephens Alternatives to Animal Experimentation. 2019;36(3):343-352. doi: 10.14573/altex.1907031 This year marks the 60th anniversary of Russell and Burch's pioneering book, The Principles of Humane …
Prosocial motives underlie scientific censorship by scientists: A perspective and research agenda
ReferenceCory J. Clark , Lee Jussim , Komi Frey , Sean T. Stevens , Musa al-Gharbi , Karl Aquino , J. Michael Bailey , Nicole Barbaro , Roy F. Baumeister , April Bleske-Rechek , David Buss , Stephen Ceci , Marco Del Giudice , Peter H. Ditto , Joseph P. Forgas , …
The Philosophical Basis of Peer Review and the Suppression of Innovation
ReferenceDavid F. Horrobin JAMA. 1990;263(10):1438-1441. doi: 10.1001/jama.1990.03440100162024 Peer review can be performed successfully only if those involved have a clear idea as to its fundamental purpose. Most authors of articles on the subject assume that the …
Exploring Bias in Scientific Peer Review: An ASCO Initiative
ReferenceNathalie D. McKenzie , Raymond Liu , Alden V. Chiu , Mariana Chavez-MacGregor , Dean Frohlich , Sarfraz Ahmad , Carolyn B. Hendricks JCO Oncology Practice. 2022;18(12):791-799. doi: 10.1200/OP.22.00275 PURPOSE: To investigate implicit bias (IB) in the …
Assessment of potential bias in research grant peer review in Canada
ReferenceRobyn Tamblyn , Nadyne Girard , Christina J. Qian , James Hanley Canadian Medical Association Journal. 2018;190(16):E489-E499. doi: 10.1503/cmaj.170901 BACKGROUND: Peer review is used to determine what research is funded and published, yet little is known …