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Is it Time for Reviewer 3 to Request Human Organ Chip Experiments Instead of Animal Validation Studies?
ReferenceDonald E. Ingber Advanced Science. 2020;7(22):2002030. doi: 10.1002/advs.202002030 For the past century, experimental data obtained from animal studies have been required by reviewers of scientific articles and grant applications to validate the …
The application of organ-on-chip models for the prediction of human pharmacokinetic profiles during drug development
ReferenceMarit Keuper-Navis , Markus Walles , Birk Poller , Adam Myszczyszyn , Thomas K. van der Made , Joanne Donkers , Hossein Eslami Amirabadi , Martijn J. Wilmer , Saskia Aan , Bart Spee , Rosalinde Masereeuw , Evita van de Steeg Pharmacological Research. …
Ancestry of cells must be considered in bioengineering
ReferenceErika Moore , Josephine B. Allen , Connie J. Mulligan , Elizabeth C. Wayne Nature Reviews Materials. 2022;7(1):2-4. doi: 10.1038/s41578-021-00397-7 Bioengineered platforms, intended to be used in the investigation of human health and disease, often …
Large-scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal cross talk
ReferenceLeqian Yu , Deirdre Logsdon , Carlos A. Pinzon-Arteaga , Jialei Duan , Toshihiko Ezashi , Yulei Wei , Ana Elisa Ribeiro Orsi , Seiya Oura , Lizhong Liu , Lei Wang , Kun Liu , Xiaoyun Ding , Linfeng Zhan , Junfei Zhang , Asrafun Nahar , Caitlen Stobbe , …
Biology-inspired microphysiological systems to advance patient benefit and animal welfare in drug development
ReferenceUwe Marx , Takafumi Akabane , Tommy B. Andersson , Elizabeth Baker , Mario Beilmann , Sonja Beken , Susanne Brendler-Schwaab , Murat Cirit , Rhiannon David , Eva-Maria Dehne , Isabell Durieux , Lorna Ewart , Suzanne C. Fitzpatrick , Olivier Frey , Florian …
Integrating Liver-Chip data into pharmaceutical decision-making processes
ReferenceDaniel Levner , Lorna Ewart Expert Opinion on Drug Discovery. 2023;18(12):1313-1320. doi: 10.1080/17460441.2023.2255127 https://doi.org/10.1080/17460441.2023.2255127 Keywords Drug-induced liver injury Liver-Chip organ-on-a-chip technology …
Microphysiological lung models to evaluate the safety of new pharmaceutical modalities: a biopharmaceutical perspective
ReferenceGR Ainslie , Davis M , Ewart L , Lieberman La , Rowlands Dj , Thorley Aj , Yoder G , Ryan Am Lab on a chip. 9;19(19). doi: 10.1039/c9lc00492k The lung is a complex organ; it is both the initial barrier for inhaled agents and the site of metabolism and …
Physiological Replication of the Human Glomerulus Using a Triple Culture Microphysiological System
ReferenceRamin Pajoumshariati , Lorna Ewart , Ville Kujala , Raymond Luc , Samantha Peel , Adam Corrigan , Heather Weber , Bramasta Nugraha , Pernille B. L. Hansen , Julie Williams Advanced Science (Weinheim, Baden-Wurttemberg, Germany). 2023:e2303131. doi: …
Optimal experimental design for efficient toxicity testing in microphysiological systems: A bone marrow application
ReferenceJonathan Cairns , Emilyanne Leonard , Kainat Khan , Conor Parks , Gareth Maglennon , Bairu Zhang , Stanley E. Lazic , Lorna Ewart , Rhiannon David Frontiers in Pharmacology. 2023;14:1142581. doi: 10.3389/fphar.2023.1142581 Introduction: Microphysiological …
Modelling human liver fibrosis in the context of non-alcoholic steatohepatitis using a microphysiological system
ReferenceTomasz Kostrzewski , Sophie Snow , Anya Lindström Battle , Samantha Peel , Zahida Ahmad , Jayati Basak , Manasa Surakala , Aurelie Bornot , Julia Lindgren , Maria Ryaboshapkina , Maryam Clausen , Daniel Lindén , Christian Maass , Lucy May Young , Adam …