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Single-cell brain organoid screening identifies developmental defects in autism
ReferenceChong Li , Jonas Simon Fleck , Catarina Martins-Costa , Thomas R. Burkard , Jan Themann , Marlene Stuempflen , Angela Maria Peer , Ábel Vertesy , Jamie B. Littleboy , Christopher Esk , Ulrich Elling , Gregor Kasprian , Nina S. Corsini , Barbara Treutlein …
Inferring and perturbing cell fate regulomes in human brain organoids
ReferenceJonas Simon Fleck , Sophie Martina Johanna Jansen , Damian Wollny , Fides Zenk , Makiko Seimiya , Akanksha Jain , Ryoko Okamoto , Malgorzata Santel , Zhisong He , J. Gray Camp , Barbara Treutlein Nature. 2023;621(7978):365-372. doi: …
Multimodal spatiotemporal phenotyping of human retinal organoid development
ReferencePhilipp Wahle , Giovanna Brancati , Christoph Harmel , Zhisong He , Gabriele Gut , Jacobo Sarabia Del Castillo , Aline Xavier da Silveira Dos Santos , Qianhui Yu , Pascal Noser , Jonas Simon Fleck , Bruno Gjeta , Dinko Pavlinic , Simone Picelli , Max Hess …
Resolving organoid brain region identities by mapping single-cell genomic data to reference atlases
ReferenceJonas Simon Fleck , Fátima Sanchís-Calleja , Zhisong He , Malgorzata Santel , Michael James Boyle , J. Gray Camp , Barbara Treutlein Cell Stem Cell. 2021;28(6):1177-1180. doi: 10.1016/j.stem.2021.03.015 Library Collection(s) Nervous system Download …
Organoid single-cell genomic atlas uncovers human-specific features of brain development
ReferenceSabina Kanton , Michael James Boyle , Zhisong He , Malgorzata Santel , Anne Weigert , Fátima Sanchís-Calleja , Patricia Guijarro , Leila Sidow , Jonas Simon Fleck , Dingding Han , Zhengzong Qian , Michael Heide , Wieland B. Huttner , Philipp Khaitovich , …
Modeled vascular microenvironments: immune-endothelial cell interactions in vitro
ReferenceJustin Silberman , Aakanksha Jha , Holly Ryan , Talia Abbate , Erika Moore Drug Delivery and Translational Research. 2021;11(6):2482-2495. doi: 10.1007/s13346-021-00970-1 The advancement of in vitro techniques enables a better understanding of biological …
Ancestral Background Is Underreported in Regenerative Engineering
ReferenceHolly Ryan , Daniel Bister , Sophia A Holliday , Jessica Boehlein , Aljae Lewis , Justin Silberman , Josephine B. Allen , Erika Moore Regenerative Engineering and Translational Medicine. 2022;8:499-503. doi: 10.1007/s40883-021-00237-8 …
A Biomaterial Model to Assess the Effects of Age in Vascularization
ReferenceJustin Silberman , Jessica Boehlein , Talia Abbate , Erika Moore Cells Tissues Organs. 2023;212(1):74-83. doi: 10.1159/000523859 As humans age, there is an increased risk for developing age-associated diseases. Many of these diseases, such as …
Human vascularised synovium-on-a-chip: a mechanically stimulated, microfluidic model to investigate synovial inflammation and monocyte recruitment
ReferenceClare L. Thompson , Timothy Hopkins , Catrin Bevan , Hazel R. C. Screen , Karina T. Wright , Martin M. Knight Biomedical Materials. 2023;18(6):065013. doi: 10.1088/1748-605X/acf976 Healthy synovium is critical for joint homeostasis. Synovial inflammation …
Mpox virus infection and drug treatment modelled in human skin organoids
ReferencePengfei Li , Spyridon T. Pachis , Guige Xu , Rick Schraauwen , Roberto Incitti , Annemarie C. de Vries , Marco J. Bruno , Maikel P. Peppelenbosch , Intikhab Alam , Karine Raymond , Qiuwei Pan Nature Microbiology. 2023:1-13. doi: 10.1038/s41564-023-01489-6 …