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Multicellular 3D Neurovascular Unit Model for Assessing Hypoxia and Neuroinflammation Induced Blood-Brain Barrier Dysfunction
ReferenceGoodwell Nzou , Robert T. Wicks , Nicole R. VanOstrand , Gehad A. Mekky , Stephanie A. Seale , Aya EL-Taibany , Elizabeth E. Wicks , Carl M. Nechtman , Eric J. Marrotte , Vishruti S. Makani , Sean V. Murphy , M. C. Seeds , John D. Jackson , Anthony J. …
Can Animal Models of Disease Reliably Inform Human Studies?
ReferenceH. Bart van der Worp , David W. Howells , Emily S. Sena , Michelle J. Porritt , Sarah Rewell , Victoria O'Collins , Malcolm R. Macleod PLOS Medicine. ;7(3):e1000245. doi: 10.1371/journal.pmed.1000245 H. Bart van der Worp and colleagues discuss the …
Phenome-wide identification of therapeutic genetic targets, leveraging knowledge graphs, graph neural networks, and UK Biobank data
ReferenceLawrence Middleton , Ioannis Melas , Chirag Vasavda , Arwa Raies , Benedek Rozemberczki , Ryan S. Dhindsa , Justin S. Dhindsa , Blake Weido , Quanli Wang , Andrew R. Harper , Gavin Edwards , Slavé Petrovski , Dimitrios Vitsios Science Advances. …
It’s Time to Review the Three Rs, to Make them More Fit for Purpose in the 21st Century
ReferenceJarrod Bailey Alternatives to Laboratory Animals. 2024;52(3):155-165. doi: 10.1177/02611929241241187 The Three Rs have become widely accepted and pursued, and are now the go-to framework that encourages the humane use of animals in science, where no other …
The (misleading) role of animal models in drug development
ReferenceThomas Hartung Frontiers in Drug Discovery. 2024;4. doi: 10.3389/fddsv.2024.1355044 Animals like mice and rats have long been used in medical research to help understand disease and test potential new treatments before human trials. However, while …
Patient-Derived Microphysiological Systems for Precision Medicine
ReferenceJihoon Ko , Jiyoung Song , Nakwon Choi , Hong Nam Kim Advanced Healthcare Materials. 2024;13(7):2303161. doi: 10.1002/adhm.202303161 Patient-derived microphysiological systems (P-MPS) have emerged as powerful tools in precision medicine that provide …
A molecular and cellular perspective on human brain evolution and tempo
ReferenceFeline W. Lindhout , Fenna M. Krienen , Katherine S. Pollard , Madeline A. Lancaster Nature. 2024;630(8017):596-608. doi: 10.1038/s41586-024-07521-x The evolution of the modern human brain was accompanied by distinct molecular and cellular …
Establishment of a heart-on-a-chip microdevice based on human iPS cells for the evaluation of human heart tissue function
ReferenceMosha Abulaiti , Yaxiaer Yalikun , Kozue Murata , Asako Sato , Mustafa M. Sami , Yuko Sasaki , Yasue Fujiwara , Kenji Minatoya , Yuji Shiba , Yo Tanaka , Hidetoshi Masumoto Scientific Reports. 2020;10(1):19201. doi: 10.1038/s41598-020-76062-w Human iPS …
Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility
ReferenceDavid Pamies , Jason Ekert , Marie-Gabrielle Zurich , Olivier Frey , Sophie Werner , Monica Piergiovanni , Benjamin S. Freedman , Adrian Kee Keong Teo , Hendrik Erfurth , Darwin R. Reyes , Peter Loskill , Pelin Candarlioglu , Laura Suter-Dick , Shan Wang …
Mitigating animal methods bias to reduce animal use and improve biomedical translation
ReferenceOwen Kavanagh , Catharine E. Krebs Science Progress. 2024;107(2):00368504241253693. doi: 10.1177/00368504241253693 Nonanimal biomedical research methods have advanced rapidly over the last decade making them the first-choice model for many researchers due …