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Updated Guidance on the Reporting of Race and Ethnicity in Medical and Science Journals
ReferenceAnnette Flanagin , Tracy Frey , Stacy L. Christiansen , AMA Manual of Style Committee JAMA. 2021;326(7):621-627. doi: 10.1001/jama.2021.13304 The goal of this guidance is to provide recommendations and suggestions that encourage fairness, equity, …
The Use of Human Tissues for Research: What Investigators Need to Know
ReferenceMarianna J. Bledsoe , William E. Grizzle Alternatives to laboratory animals : ATLA. 2022;50(4):265-274. doi: 10.1177/02611929221107933 While laboratory animals are necessary for some aspects of the development of biomedical advances, including those of …
The use of human tissue in safety assessment
ReferenceSamuel J. Jackson , Helen Prior , Anthony Holmes Journal of Pharmacological and Toxicological Methods. 2018;93:29-34. doi: 10.1016/j.vascn.2018.05.003 Introduction The safety-related failure of drugs during clinical phases of development is a significant …
Public consultation in the evaluation of animal research protocols
ReferenceMichael W. Brunt , Daniel M. Weary PLOS ONE. ;16(12):e0260114. doi: 10.1371/journal.pone.0260114 One response to calls for increased openness in animal research is to make protocols publicly accessible, but it is unclear what type of input the public …
Modeling human immune responses to vaccination in vitro
ReferenceElena Morrocchi , Simon van Haren , Paolo Palma , Ofer Levy Trends in Immunology. 2024;45(1):32-47. doi: 10.1016/j.it.2023.11.002 https://www.cell.com/trends/immunology/abstract/S1471-4906(23)00256-9 Keywords adjuvant human in vitro modeling Tissue …
Common pitfalls in preclinical cancer target validation
ReferenceWilliam G. Kaelin Nature Reviews. Cancer. 2017;17(7):425-440. doi: 10.1038/nrc.2017.32 An alarming number of papers from laboratories nominating new cancer drug targets contain findings that cannot be reproduced by others or are simply not robust enough …
Cellular and axonal transport phenotypes due to the C9ORF72 HRE in iPSC motor and sensory neurons
ReferenceJakub Scaber , Iona Thomas-Wright , Alex J. Clark , Yinyan Xu , Björn F. Vahsen , Mireia Carcolé , Ruxandra Dafinca , Lucy Farrimond , Adrian M. Isaacs , David L. Bennett , Kevin Talbot Stem Cell Reports. 2024;19(7):957-972. doi: …
Self-assembling 3D vessel-on-chip model with hiPSC-derived astrocytes
ReferenceDennis M. Nahon , Marc Vila Cuenca , Francijna E. van den Hil , Michel Hu , Tessa de Korte , Jean-Philippe Frimat , Arn M. J. M. van den Maagdenberg , Christine L. Mummery , Valeria V. Orlova Stem Cell Reports. 2024;19(7):946-956. doi: …
Organ-on-a-chip models for elucidating the cellular biology of infectious diseases
ReferenceFuki Yokoi , Sayaka Deguchi , Kazuo Takayama Biochimica Et Biophysica Acta. Molecular Cell Research. 2023;1870(6):119504. doi: 10.1016/j.bbamcr.2023.119504 Infectious diseases are caused by the invasion of pathogens into a host. To explore the mechanisms …
Failure-to-success ratios, transition probabilities and phase lengths for prophylactic vaccines versus other pharmaceuticals in the development pipeline
ReferenceMatthew M. Davis , Amy T. Butchart , John R. C. Wheeler , Margaret S. Coleman , Dianne C. Singer , Gary L. Freed Vaccine. 2011;29(51):9414-9416. doi: 10.1016/j.vaccine.2011.09.128 Research and development of prophylactic vaccines carries a high risk of …