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A novel preclinical model of the normal human breast
ReferenceAnthony J. Wilby , Sara Cabral , Nastaran Zoghi , Sacha J. Howell , Gillian Farnie , Hannah Harrison Journal of Mammary Gland Biology and Neoplasia. 2024;29(1):9. doi: 10.1007/s10911-024-09562-4 Improved screening and treatment have decreased breast …
Dissolved gases from pressure changes in the lungs elicit an immune response in human peripheral blood
ReferenceAbigail G. Harrell , Stephen R. Thom , C. Wyatt Shields IV Bioengineering & Translational Medicine. :e10657. doi: 10.1002/btm2.10657 Conventional dogma suggests that decompression sickness (DCS) is caused by nitrogen bubble nucleation in the blood vessels …
Gephyrin promotes autonomous assembly and synaptic localization of GABAergic postsynaptic components without presynaptic GABA release
ReferenceEtta Carricaburu , Orion Benner , Scott R. Burlingham , Carolina Dos Santos Passos , Natalia Hobaugh , Charles H. Karr , Soham Chanda Proceedings of the National Academy of Sciences. 2024;121(26):e2315100121. doi: 10.1073/pnas.2315100121 Synapses …
Bioengineered human colon organoids with in vivo-like cellular complexity and function
ReferenceOlga Mitrofanova , Mikhail Nikolaev , Quan Xu , Nicolas Broguiere , Irineja Cubela , J. Gray Camp , Michael Bscheider , Matthias P. Lutolf Cell Stem Cell. 2024;31(8):1175-1186.e7. doi: 10.1016/j.stem.2024.05.007 Organoids and organs-on-a-chip have emerged …
Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2
ReferenceMohammed R. Shaker , Andrii Slonchak , Bahaa Al-mhanawi , Sean D. Morrison , Julian D. J. Sng , Justin Cooper-White , Alexander A. Khromykh , Ernst J. Wolvetang Science Advances. 2024;10(23):eadj4735. doi: 10.1126/sciadv.adj4735 Why individuals with Down …
Patient-derived organoid biobank identifies epigenetic dysregulation of intestinal epithelial MHC-I as a novel mechanism in severe Crohn’s Disease
ReferenceThomas W. Dennison , Rachel D. Edgar , Felicity Payne , Komal M. Nayak , Alexander D. B. Ross , Aurelie Cenier , Claire Glemas , Federica Giachero , April R. Foster , Rebecca Harris , Judith Kraiczy , Camilla Salvestrini , Georgia Stavrou , Franco …
60 Years of the 3Rs symposium: Lessons learned and the road ahead
ReferenceMichael Balls , Rolf Bass , Rodger Curren , Julia Fentem , Alan Goldberg , Thomas Hartung , Kathrin Herrmann , Nicole C. Kleinstreuer , Lisa Libowitz , John Parascandola , Andrew Rowan , Horst Spielmann , Martin L. Stephens , Russell S. Thomas , Katya …
Embryonic origin of two ASD subtypes of social symptom severity: the larger the brain cortical organoid size, the more severe the social symptoms
ReferenceEric Courchesne , Vani Taluja , Sanaz Nazari , Caitlin M. Aamodt , Karen Pierce , Kuaikuai Duan , Sunny Stophaeros , Linda Lopez , Cynthia Carter Barnes , Jaden Troxel , Kathleen Campbell , Tianyun Wang , Kendra Hoekzema , Evan E. Eichler , Joao V. Nani , …
Cervical extracellular matrix hydrogel optimizes tumor heterogeneity of cervical squamous cell carcinoma organoids
ReferenceHaonan Song , Haoyuan Jiang , Weichu Hu , Yan Hai , Yihuan Cai , Hu Li , Yuru Liao , Yi Huang , Xiaogang Lv , Yefei Zhang , Jiping Zhang , Yan Huang , Xiaomei Liang , Hao Huang , Xinhua Lin , Yifeng Wang , Xiao Yi Science Advances. 2024;10(20):eadl3511. …
A miniaturised semi-dynamic in-vitro model of human digestion
ReferenceVictor Calero , PatrÃcia M. Rodrigues , Tiago Dias , Alar Ainla , Adriana Vilaça , Lorenzo Pastrana , Miguel Xavier , Catarina Gonçalves Scientific Reports. 2024;14:11923. doi: 10.1038/s41598-024-54612-w Reliable in-vitro digestion models that are able to …