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Alzheimer's Disease, and Breast and Prostate Cancer Research: Translational Failures and the Importance to Monitor Outputs and Impact of Funded Research
ReferenceFrancesca Pistollato , Camilla Bernasconi , Janine McCarthy , Ivana Campia , Christian Desaintes , Clemens Wittwehr , Pierre Deceuninck , Maurice Whelan Animals (Basel). 2020;10(7):1194. doi: 10.3390/ani10071194 Dementia and cancer are becoming …
Embedding Biomimetic Vascular Networks via Coaxial Sacrificial Writing into Functional Tissue
ReferencePaul P. Stankey , Katharina T. Kroll , Alexander J. Ainscough , Daniel S. Reynolds , Alexander Elamine , Ben T. Fichtenkort , Sebastien G.M. Uzel , Jennifer A. Lewis Advanced Materials. 2024. doi: 10.1002/adma.202401528 Printing human tissues and organs …
Naturally derived Heme-Oxygenase 1 inducers attenuate inflammatory responses in human dendritic cells and T cells: relevance for psoriasis treatment
ReferenceNicole K. Campbell , Hannah K. Fitzgerald , Anna Malara , Roisin Hambly , Cheryl M. Sweeney , Brian Kirby , Jean M. Fletcher , Aisling Dunne Scientific Reports. 2018;8(1):10287. doi: 10.1038/s41598-018-28488-6 Psoriasis is a chronic autoimmune disease …
Inhibition of IL-17 and IL-23 in Human Keratinocytes by the A3 Adenosine Receptor Agonist Piclidenoson
ReferenceShira Cohen , Faina Barer , Inbal Itzhak , Michael H. Silverman , Pnina Fishman Journal of Immunology Research. 2018;2018:2310970. doi: 10.1155/2018/2310970 Interleukin-17 and interleukin-23 play major roles in the inflammatory process in psoriasis. The …
Challenges in Psoriasis Research: A Systematic Review of Preclinical Models
ReferenceAna Ubago-Rodríguez , María I. Quiñones-Vico , Manuel Sánchez-Díaz , Raquel Sanabria-de la Torre , Álvaro Sierra-Sánchez , Trinidad Montero-Vílchez , Ana Fernández-González , Salvador Arias-Santiago Dermatology. 2024;240(4):620-652. doi: 10.1159/000538993 …
Immune-competent human skin disease models
ReferenceLambert I. J. C. Bergers , Christianne M. A. Reijnders , Lenie J. van den Broek , Sander W. Spiekstra , Tanja D. de Gruijl , Ester M. Weijers , Susan Gibbs Drug Discovery Today. 2016;21(9):1479-1488. doi: 10.1016/j.drudis.2016.05.008 All skin diseases …
A therapy for suppressing canonical and noncanonical SARS-CoV-2 viral entry and an intrinsic intrapulmonary inflammatory response
ReferenceSandra L. Leibel , Rachael N. McVicar , Rabi Murad , Elizabeth M. Kwong , Alex E. Clark , Asuka Alvarado , Bethany A. Grimmig , Ruslan Nuryyev , Randee E. Young , Jamie C. Lee , Weiqi Peng , Yanfang P. Zhu , Eric Griffis , Cameron J. Nowell , Brian James …
Nonclinical evaluation of chronic cardiac contractility modulation on 3D human engineered cardiac tissues
ReferenceTromondae K. Feaster , Jourdan K. Ewoldt , Anna Avila , Maura Casciola , Akshay Narkar , Christopher S. Chen , Ksenia Blinova Journal of Cardiovascular Electrophysiology. 2024;35(5):895-905. doi: 10.1111/jce.16222 Introduction Cardiac contractility …
Will Labour help us transition away from pre-clinical animal research?
ReferencePandora Pound , Merel Ritskes-Hoitinga BMJ. 2024;386:q1600. doi: 10.1136/bmj.q1600 We must develop a funded, evidence based transition programme to enable a shift to safe and effective human biology based approaches in research …
Animal research is not always king: researchers should explore the alternatives
ReferenceEditorial Nature. 2024;631(8021):481-481. doi: 10.1038/d41586-024-02314-8 Technological advances can reduce the numbers of laboratory animals used in studies — but they need to be carefully validated. https://www.nature.com/articles/d41586-024-02314-8 …