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Human Lung Stem Cell-Based Alveolospheres Provide Insights into SARS-CoV-2-Mediated Interferon Responses and Pneumocyte Dysfunction
ReferenceHiroaki Katsura , Vishwaraj Sontake , Aleksandra Tata , Yoshihiko Kobayashi , Caitlin E. Edwards , Brook E. Heaton , Arvind Konkimalla , Takanori Asakura , Yu Mikami , Ethan J. Fritch , Patty J. Lee , Nicholas S. Heaton , Richard C. Boucher , Scott H. …
3D culture models to study SARS-CoV-2 infectivity and antiviral candidates: From spheroids to bioprinting
ReferenceBruna A. G. de Melo , Julia C. Benincasa , Elisa M. Cruz , Juliana Terzi Maricato , Marimelia A. Porcionatto Biomedical Journal. 2021;44(1):31-42. doi: 10.1016/j.bj.2020.11.009 The pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 …
A materials-science perspective on tackling COVID-19
ReferenceZhongmin Tang , Na Kong , Xingcai Zhang , Yuan Liu , Ping Hu , Shan Mou , Peter Liljeström , Jianlin Shi , Weihong Tan , Jong Seung Kim , Yihai Cao , Robert Langer , Kam W. Leong , Omid C. Farokhzad , Wei Tao Nature Reviews Materials. 2020;5(11):847-860. …
Inhibition of SARS-CoV-2 Infections in Engineered Human Tissues Using Clinical-Grade Soluble Human ACE2
ReferenceVanessa Monteil , Hyesoo Kwon , Patricia Prado , Astrid Hagelkrüys , Reiner A. Wimmer , Martin Stahl , Alexandra Leopoldi , Elena Garreta , Carmen Hurtado Del Pozo , Felipe Prosper , Juan Pablo Romero , Gerald Wirnsberger , Haibo Zhang , Arthur S. Slutsky …
Potential Applications of Microfluidics to Acute Kidney Injury Associated with Viral Infection
ReferenceHolly Ryan , Chelsey S. Simmons Cellular and Molecular Bioengineering. 2020;13(4):305-311. doi: 10.1007/s12195-020-00649-6 The kidneys are susceptible to adverse effects from many diseases, including several that are not tissue-specific. Acute kidney …
Human Organs-on-Chips for Virology
ReferenceHuaqi Tang , Yasmine Abouleila , Longlong Si , Ana Maria Ortega-Prieto , Christine L. Mummery , Donald E. Ingber , Alireza Mashaghi Trends in Microbiology. 2020;28(11):934-946. doi: 10.1016/j.tim.2020.06.005 While conventional in vitro culture systems and …
SARS-CoV-2 infection of primary human lung epithelium for COVID-19 modeling and drug discovery
ReferenceA. Mulay , B. Konda , G. Garcia , C. Yao , S. Beil , C. Sen , A. Purkayastha , J. K. Kolls , D. A. Pociask , P. Pessina , J. Sainz de Aja , C. Garcia-de-Alba , C. F. Kim , B. Gomperts , V. Arumugaswami , B. R. Stripp bioRxiv: The Preprint Server for …
Rapid endotheliitis and vascular damage characterize SARS-CoV-2 infection in a human lung-on-chip model
ReferenceVivek V. Thacker , Kunal Sharma , Neeraj Dhar , Gian-Filippo Mancini , Jessica Sordet-Dessimoz , John D. McKinney EMBO reports. 2021;22(6):e52744. doi: 10.15252/embr.202152744 Severe cases of SARS-CoV-2 infection are characterized by hypercoagulopathies …
SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids
ReferenceLaura Pellegrini , Anna Albecka , Donna L. Mallery , Max J. Kellner , David Paul , Andrew P. Carter , Leo C. James , Madeline A. Lancaster Cell Stem Cell. 2020;27(6):951-961.e5. doi: 10.1016/j.stem.2020.10.001 Coronavirus disease 2019 (COVID-19), caused …
SARS-CoV-2 productively infects human gut enterocytes
ReferenceMart M. Lamers , Joep Beumer , Jelte van der Vaart , Kèvin Knoops , Jens Puschhof , Tim I. Breugem , Raimond B. G. Ravelli , J. Paul van Schayck , Anna Z. Mykytyn , Hans Q. Duimel , Elly van Donselaar , Samra Riesebosch , Helma J. H. Kuijpers , Debby …