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Biomimetic Human Disease Model of SARS-CoV-2-Induced Lung Injury and Immune Responses on Organ Chip System
ReferenceMin Zhang , Peng Wang , Ronghua Luo , Yaqing Wang , Zhongyu Li , Yaqiong Guo , Yulin Yao , Minghua Li , Tingting Tao , Wenwen Chen , Jianbao Han , Haitao Liu , Kangli Cui , Xu Zhang , Yongtang Zheng , Jianhua Qin Advanced Science. 2021;8(3):2002928. doi: …
COVID-19 highlights the model dilemma in biomedical research
ReferencePartho Protim Adhikary , Qurrat Ul Ain , Andreas Christian Hocke , Sarah Hedtrich Nature Reviews Materials. 2021;6(5):374-376. doi: 10.1038/s41578-021-00305-z Scientists worldwide struggle to identify suitable animal models to study SARS-CoV-2 infections. …
The mini lungs and other organoids helping to beat COVID
ReferenceSmriti Mallapaty Nature. 2021;593(7860):492-494. doi: 10.1038/d41586-021-01395-z Virologists have infected millions of miniature organs with SARS-CoV-2, to learn how the virus wreaks havoc and how to stop it. …
High-throughput human primary cell-based airway model for evaluating influenza, coronavirus, or other respiratory viruses in vitro
ReferenceA. L. Gard , R. J. Luu , C. R. Miller , R. Maloney , B. P. Cain , E. E. Marr , D. M. Burns , R. Gaibler , T. J. Mulhern , C. A. Wong , J. Alladina , J. R. Coppeta , P. Liu , J. P. Wang , H. Azizgolshani , R. Fennell Fezzie , J. L. Balestrini , B. C. …
Advancing lung organoids for COVID-19 research
ReferenceJelte van der Vaart , Mart M. Lamers , Bart L. Haagmans , Hans Clevers Disease Models & Mechanisms. 2021;14(6):dmm049060. doi: 10.1242/dmm.049060 The COVID-19 pandemic has emphasised the need to develop effective treatments to combat emerging viruses. …
Cell response analysis in SARS-CoV-2 infected bronchial organoids
ReferenceEmi Sano , Tatsuya Suzuki , Rina Hashimoto , Yumi Itoh , Ayaka Sakamoto , Yusuke Sakai , Akatsuki Saito , Daisuke Okuzaki , Daisuke Motooka , Yukiko Muramoto , Takeshi Noda , Tomohiko Takasaki , Jun-Ichi Sakuragi , Shohei Minami , Takeshi Kobayashi , …
Human pluripotent stem cell-based organoids and cell platforms for modelling SARS-CoV-2 infection and drug discovery
ReferenceAlice Maria Giani , Shuibing Chen Stem Cell Research. 2021;53:102207. doi: 10.1016/j.scr.2021.102207 The coronavirus disease 2019 (COVID-19) global pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected over …
TMPRSS2 and TMPRSS4 promote SARS-CoV-2 infection of human small intestinal enterocytes
ReferenceRuochen Zang , Maria Florencia Gomez Castro , Broc T. McCune , Qiru Zeng , Paul W. Rothlauf , Naomi M. Sonnek , Zhuoming Liu , Kevin F. Brulois , Xin Wang , Harry B. Greenberg , Michael S. Diamond , Matthew A. Ciorba , Sean P. J. Whelan , Siyuan Ding …
Human organoid systems reveal in vitro correlates of fitness for SARS-CoV-2 B.1.1.7
ReferenceMart M. Lamers , Tim I. Breugem , Anna Z. Mykytyn , Yiquan Wang , Nathalie Groen , Kèvin Knoops , Debby Schipper , Jelte van der Vaart , Charlotte D. Koopman , Jingshu Zhang , Douglas C. Wu , Petra B. van den Doel , Theo Bestebroer , Corine H. …
Airway and Alveoli Organoids as Valuable Research Tools in COVID-19
ReferenceMiriane de Oliveira , Maria T. De Sibio , Felipe A. S. Costa , Marna E. Sakalem ACS Biomaterials Science & Engineering. 2021;7(8):3487-3502. doi: 10.1021/acsbiomaterials.1c00306 The coronavirus disease 2019 (COVID-19), caused by the novel coronavirus, …