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Threats to validity in the design and conduct of preclinical efficacy studies: a systematic review of guidelines for in vivo animal experiments
ReferenceValerie C. Henderson , Jonathan Kimmelman , Dean Fergusson , Jeremy M. Grimshaw , Dan G. Hackam PLoS Medicine. 2013;10(7):e1001489. doi: 10.1371/journal.pmed.1001489 BACKGROUND: The vast majority of medical interventions introduced into clinical …
Evaluation of Excess Significance Bias in Animal Studies of Neurological Diseases
ReferenceKonstantinos K. Tsilidis , Orestis A. Panagiotou , Emily S. Sena , Eleni Aretouli , Evangelos Evangelou , David W. Howells , Rustam Al-Shahi Salman , Malcolm R. Macleod , John P. A. Ioannidis PLOS Biology. ;11(7):e1001609. doi: …
The need for randomization in animal trials: an overview of systematic reviews
ReferenceJennifer A. Hirst , Jeremy Howick , Jeffrey K. Aronson , Nia Roberts , Rafael Perera , Constantinos Koshiaris , Carl Heneghan PloS One. 2014;9(6):e98856. doi: 10.1371/journal.pone.0098856 BACKGROUND AND OBJECTIVES: Randomization, allocation concealment, …
Technical framework for enabling high quality measurements in new approach methodologies (NAMs)
ReferenceElijah J. Petersen , John T. Elliott , John Gordon , Nicole C. Kleinstreuer , Emily Reinke , Mattias Roesslein , Blaza Toman Alternatives to Animal Experimentation. 2023;40(1):174-186. doi: 10.14573/altex.2205081 New approach methodologies (NAMs) are in …
Guidance document on Good Cell and Tissue Culture Practice 2.0 (GCCP 2.0)
ReferenceDavid Pamies , Marcel Leist , Sandra Coecke , Gerard Bowe , David G. Allen , Gerhard Gstraunthaler , Anna Bal-Price , Francesca Pistollato , Rob B. M. De Vries , Helena T. Hogberg , Thomas Hartung , Glyn Stacey Alternatives to Animal Experimentation. …
Fluid flow to mimic organ function in 3D in vitro models
ReferenceYago Juste-Lanas , Silvia Hervas-Raluy , José Manuel GarcÃa-Aznar , Alejandra González-Loyola APL Bioengineering. 2023;7(3):031501. doi: 10.1063/5.0146000 Many different strategies can be found in the literature to model organ physiology, tissue …
Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids
ReferenceJenna M. Kastenschmidt , Suhas Sureshchandra , Aarti Jain , Jenny E. Hernandez-Davies , Rafael De Assis , Zachary W. Wagoner , Andrew M. Sorn , Mahina Tabassum Mitul , Aviv I. Benchorin , Elizabeth Levendosky , Gurpreet Ahuja , Qiu Zhong , Douglas Trask , …
Microphysiological Systems Evaluation: Experience of TEX-VAL Tissue Chip Testing Consortium
ReferenceIvan Rusyn , Courtney Sakolish , Yuki Kato , Clifford Stephan , Leoncio Vergara , Philip Hewitt , Vasanthi Bhaskaran , Myrtle Davis , Rhiannon N. Hardwick , Stephen S. Ferguson , Jason P. Stanko , Piyush Bajaj , Karissa Adkins , Nisha S. Sipes , E. Sidney …
Platforms for Personalized Polytherapeutics Discovery in COVID-19
ReferenceChristopher Hopkins , Chidinma Onweni , Victoria Zambito , DeLisa Fairweather , Kathryn McCormick , Hideki Ebihara , Thomas Caulfield , Yu Shrike Zhang , W. David Freeman Journal of Molecular Biology. 2021;433(10):166945. doi: 10.1016/j.jmb.2021.166945 …
Studying SARS-CoV-2 infectivity and therapeutic responses with complex organoids
ReferenceKevin G. Chen , Kyeyoon Park , Jason R. Spence Nature Cell Biology. 2021;23(8):822-833. doi: 10.1038/s41556-021-00721-x Clinical management of patients with severe complications of COVID-19 has been hindered by a lack of effective drugs and a failure to …