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Measurement challenges and causes of incomplete results reporting of biomedical animal studies: Results from an interview study
ReferenceTill Bruckner , Susanne Wieschowski , Miriam Heider , Susanne Deutsch , Natascha Drude , Ulf Tölch , André Bleich , René Tolba , Daniel Strech PLOS ONE. ;17(8):e0271976. doi: 10.1371/journal.pone.0271976 Background Existing evidence indicates that a …
Se(XY) matters: the importance of incorporating sex in microphysiological models
ReferenceSonya Kouthouridis , Eleanor Robson , Alicia Hartung , Sandeep Raha , Boyang Zhang Trends in Biotechnology. 2022;40(11):1284-1298. doi: 10.1016/j.tibtech.2022.04.005 The development of microphysiological models is currently at the forefront of preclinical …
How viable are alternatives to animal testing in determining the toxicities of therapeutic drugs?
ReferenceMichael Balls , Jarrod Bailey , Robert D. Combes Expert Opinion on Drug Metabolism & Toxicology. 2019;15(12):985-987. doi: 10.1080/17425255.2019.1694662 Keywords Alternative test methods Animal Testing Alternatives Animals Drug development Drug …
Does the stress inherent to laboratory life and experimentation on animals adversely affect research data?
ReferenceJarrod Bailey Alternatives to Laboratory Animals. 2017;45(6):299-301. doi: 10.1177/026119291704500605 https://journals.sagepub.com/doi/10.1177/026119291704500605 Keywords animal experimentation Animal Husbandry animal welfare Animals Laboratory Animal …
Non-human primates in neuroscience research: The case against its scientific necessity
ReferenceJarrod Bailey , Kathy Taylor Alternatives to Laboratory Animals. 2016;44(1):43-69. doi: 10.1177/026119291604400101 Public opposition to non-human primate (NHP) experiments is significant, yet those who defend them cite minimal harm to NHPs and substantial …
Building confidence in non-animal methods: Practical examples of collaboration between regulators, researchers and industry
ReferenceCatherine Mahony Computational Toxicology. 2019;10:78-80. doi: 10.1016/j.comtox.2019.01.003 In the field of systemic toxicity practical solutions are being derived through collaborative efforts to replace repeat dose toxicity testing for the Cosmetic …
New approach methodologies in human regulatory toxicology – Not if, but how and when!
ReferenceSebastian Schmeisser , Andrea Miccoli , Martin von Bergen , Elisabet Berggren , Albert Braeuning , Wibke Busch , Christian Desaintes , Anne Gourmelon , Roland Grafström , Joshua Harrill , Thomas Hartung , Matthias Herzler , George E. N. Kass , Nicole …
Comparison of treatment effects between animal experiments and clinical trials: systematic review
ReferencePablo Perel , Ian Roberts , Emily Sena , Philipa Wheble , Catherine Briscoe , Peter Sandercock , Malcolm Macleod , Luciano E. Mignini , Pradeep Jayaram , Khalid S. Khan BMJ. 2007;334:197. doi: 10.1136/bmj.39048.407928.BE OBJECTIVE: To examine concordance …
An analysis of the use of animal models in predicting human toxicology and drug safety
ReferenceJarrod Bailey , Michelle Thew , Michael Balls Alternatives to Laboratory Animals. 2014;42(3):181-199. doi: 10.1177/026119291404200306 Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The …
How predictive and productive is animal research?
ReferenceFiona Godlee BMJ. 2014;348:g3719. doi: 10.1136/bmj.g3719 It’s more than 20 years since Doug Altman wrote his scorching editorial in The BMJ on “the scandal of medical research” (doi:10.1136/bmj.308.6924.283). Earlier this year The BMJ ’s former editor …